Sinonasal melanoma: a systematic review of the prognostic factors

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dc.creatorFlavia Sirotheau Correa Pontes
dc.creatorLucas Lacerda de Souza
dc.creatorCiro Dantas Soares
dc.creatorFelipe Paiva Fonseca
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorDe Abreu
dc.creatorFernandes
dc.creatorRodrigues
dc.creatorDo Nascimento
dc.creatorVasconcelos
dc.creatorCorrêa
dc.date.accessioned2023-10-18T20:09:57Z
dc.date.accessioned2025-09-08T23:32:35Z
dc.date.available2023-10-18T20:09:57Z
dc.date.issued2020-05
dc.identifier.doihttps://doi.org/10.1016/j.ijom.2019.11.001
dc.identifier.issn09015027
dc.identifier.urihttps://hdl.handle.net/1843/59643
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery
dc.rightsAcesso Restrito
dc.subjectMelanoma, amelanotic
dc.subjectRecurrence
dc.subjectParanasal sinuses
dc.subjectSurvival
dc.subjectPrognosis
dc.subjectTherapeutics
dc.subjectNose
dc.subjectEpistaxis
dc.subjectNeoplasm metastasis
dc.subject.othernome revista International journal of oral and maxillofacial surgery busca dia 29 do 09 2023 fao clinica assunto Melanoma, Amelanotic
dc.titleSinonasal melanoma: a systematic review of the prognostic factors
dc.typeArtigo de periódico
local.citation.epage557
local.citation.issue5
local.citation.spage549
local.citation.volume49
local.description.resumoThe objective was to evaluate the available published data on sinonasal melanoma and analyse its clinical features, treatment modalities, and prognostic factors. An electronic search was undertaken in March 2018 in multiple databases. Eligibility criteria included publications with sufficient clinical, histological, and immunohistochemical information to confirm the diagnosis. Seventy-three publications (439 cases) were included. The lesion was more prevalent in females than in males. There was a higher prevalence in the seventh and eighth decades of life. The lesions mainly presented as epistaxis and commonly involved the nasal cavity. Age (>67.6 years; P=0.0012), primary location (middle turbinate; P=0.0112), disease stage (advanced disease stage; P=0.0026), treatment (radiotherapy; P=0.0111), recurrence (recurrence presented; P=0.0137), and distant metastasis (distant metastasis presented; P=0.0011) were independently associated with a lower survival rate. Recurrence was significantly correlated with age (>67.6 years; P=0.0021), sex (males tended to present a higher recurrence rate than females; P=0.0051), disease stage (stages III and IV presented a higher recurrence rate than stages I and II; P=0.0331), and histological type (amelanotic lesions presented a higher index of recurrence than melanotic lesions; P=0.0095). In conclusion, sinonasal melanoma is a neoplasm with a poor prognosis, presenting a 30.69% possibility of survival after 5 years.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0901502719313992?via%3Dihub

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