Impact of pre-transplant carbapenem-resistant enterobacterales colonization and/or infection on solid organ transplant outcomes

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dc.creatorSarahtaimur
dc.creatorEmily Blumberg
dc.creatorMichael j. Satlin
dc.creatorLarissa Pisney
dc.creatorWanessa Trindade Clemente
dc.creatorMarcus j. Zervos
dc.creatorRicardo m. la Hoz
dc.creatorShirish Huprikar
dc.creatorStephanie m. Pouch
dc.creatorNicole Zubizarreta
dc.creatorMadhu Mazumdar
dc.creatorMeenakshi Rana
dc.creatorGopi Patel
dc.creatorMaristela Pinnheiro Freire
dc.creatorRebecca Pellett Madan
dc.creatorEun Jeong Kwak
dc.date.accessioned2023-07-04T19:55:43Z
dc.date.accessioned2025-09-09T00:31:17Z
dc.date.available2023-07-04T19:55:43Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doi10.1111/ctr.14239
dc.identifier.issn09020063
dc.identifier.urihttps://hdl.handle.net/1843/55773
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Transplantation
dc.rightsAcesso Restrito
dc.subjectKlebsiella pneumoniae
dc.subjectTransplante de orgãos
dc.subject.otherCarbapenem-resistant enterobacterales
dc.subject.otherMultidrug-resistan organisms
dc.subject.otherSolid organ transplantation
dc.titleImpact of pre-transplant carbapenem-resistant enterobacterales colonization and/or infection on solid organ transplant outcomes
dc.typeArtigo de periódico
local.citation.epage7
local.citation.issue4
local.citation.spage1
local.citation.volume35
local.description.resumoThe impact of pre-transplant (SOT) carbapenem-resistant Enterobacterales (CRE) colo nization or infection on post-SOT outcomes is unclear. We conducted a multi-center, international, cohort study of SOT recipients, with microbiologically diagnosed CRE colonization and/or infection pre-SOT. Sixty adult SOT recipients were included (livern = 30, hearts n = 17). Klebsiella pneumoniae (n = 47, 78%) was the most common pre SOT CRE species. Median time from CRE detection to SOT was 2.32 months (IQR 0.33–10.13). Post-SOT CRE infection occurred in 40% (n = 24/60), at a median of 9 days (IQR 7–17), and most commonly due to K pneumoniae (n = 20/24, 83%). Of those infected, 62% had a surgical site infection, and 46% had bloodstream infection.Patients with post-SOT CRE infection more commonly had a liver transplant (16, 67%vs. 14, 39%; p =.0350) or pre-SOT CRE BSI (11, 46% vs. 7, 19%; p =.03). One-year post-SOT survival was 77%, and those with post-SOT CRE infection had a 50% less chance of survival vs. uninfected (0.86, 95% CI, 0.76–0.97 vs. 0.34, 95% CI 0.08–1.0, p =.0204). Pre-SOT CRE infection or colonization is not an absolute contraindication to SOT and is more common among abdominal SOT recipients, those with pre-SOT CRE BSI, and those with early post-SOT medical and surgical complications.
local.identifier.orcidhttps://orcid.org/0000-0003-0848-3740
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/ctr.14239

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