Compatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process

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dc.creatorCarolina Rossi Gouvêa Silva
dc.creatorSílvia Ligório Fialho
dc.creatorJamile Barbosa
dc.creatorBárbara Caroline Rodrigues de Araújo
dc.creatorGuilherme Carneiro
dc.creatorRita de Cássia de Oliveira Sebastião
dc.creatorWagner da Nova Mussel
dc.creatorMaria Irene Yoshida
dc.creatorMaria Betânia de Freitas Marques
dc.date.accessioned2023-03-02T14:52:21Z
dc.date.accessioned2025-09-08T23:46:18Z
dc.date.available2023-03-02T14:52:21Z
dc.date.issued2021-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://dx.doi.org/10.21577/0103-5053.20200218
dc.identifier.issn1678-4790
dc.identifier.urihttps://hdl.handle.net/1843/50603
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectQuímica farmacêutica
dc.subjectCinética química
dc.subjectFourier, Espectroscopia de infravermelho por transformada de
dc.subjectRaios X - Difração
dc.subjectAnálise térmica
dc.subjectTermogravimetria
dc.subjectCalorimetria
dc.subjectTecnologia farmacêutica - Controle de qualidade
dc.subjectMedicamentos - Análise
dc.subjectExcipientes
dc.subject.otherImmunosuppressive drug
dc.subject.otherGood manufacturing practices
dc.subject.otherSolid-state properties
dc.subject.otherActivation energy
dc.subject.otherVyazovkin method
dc.subject.otherFukui function
dc.titleCompatibility by a nonisothermal kinetic study of azathioprine associated with usual excipients in the product quality review process
dc.typeArtigo de periódico
local.citation.epage651
local.citation.issue3
local.citation.spage638
local.citation.volume32
local.description.resumoAzathioprine is an immunosuppressive drug for several inflammatory disorders. Due to its clinical relevance, to explore the solid-state properties for excipient compatibility in the product quality review process is essential. Fourier transform infrared spectroscopy, powder X-ray diffraction and thermal analysis (thermogravimetry/derivative thermogravimetry (TG/DTG), differential thermal analysis (DTA), and differential scanning calorimetry (DSC)) were applied. The compatibility studies evidenced that starch pregelatinized, colloidal silicon dioxide, and talc are fully compatible with azathioprine. However, stearic acid, magnesium stearate, and mannitol are incompatible after heat supply at temperatures easily reached by industrial processing. The nonlinear Vyazovkin isoconversional treatment performed the kinetic study of the thermal degradation. The activation energies were determined to clarify the influence of each excipient on the thermal drug stability, an essential procedure in the pharmaceutical development, and all over the commercial live span, in Good Manufacturing Practices.
local.identifier.orcidhttps://orcid.org/0000-0001-8068-5211
local.identifier.orcidhttps://orcid.org/0000-0002-0367-8170
local.identifier.orcidhttps://orcid.org/0000-0002-5158-7783
local.identifier.orcidhttps://orcid.org/0000-0002-9768-9830
local.identifier.orcidhttps://orcid.org/0000-0002-6795-9457
local.identifier.orcidhttps://orcid.org/0000-0002-0561-2343
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://jbcs.sbq.org.br/default.asp?ed=309

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