Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil

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dc.creatorHegger Fritsch
dc.creatorJaqueline Lima
dc.creatorLenisa Santos
dc.creatorLuciana Silva
dc.creatorVanessa Nardy
dc.creatorMarcela Kelly Gómez Astete
dc.creatorBeatriz Senra Álvares da Silva Santos
dc.creatorNágila Rocha Aguilar
dc.creatorMaria Isabel Maldonado Coelho Guedes
dc.creatorGuilherme Canhestro de Faria
dc.creatorRonaldo Furtini
dc.creatorFelicidade Mota Pereira
dc.creatorSafira Rachel Milanez Drumond
dc.creatorGabriel Muricy Cunha
dc.creatorMarcia São Pedro Leal Souza
dc.creatorRonaldo de Jesus
dc.creatorSara A. Franco Guimarães
dc.creatorItalo Coelho Nuno
dc.creatorIan Carlos Brito de Santana
dc.creatorJosé Eduardo Ungar de sá
dc.creatorGeorge Roma Santos
dc.creatorWilladesmon Santos Silva
dc.creatorErica Azevedo Costa
dc.creatorThiago Ferreira Guedes
dc.creatorEmerson Luiz Lima Araújo
dc.creatorRodrigo Fabiano do Carmo Said
dc.creatorCarlos Frederico Campelo de Albuquerque
dc.creatorCassio Roberto Leonel Peterka
dc.creatorAlessandro Pecego Martins Romano
dc.creatorRivaldo Venâncio da Cunha
dc.creatorAna Maria Bispo de Filippis
dc.creatorArabela Leal e Silva de Mello
dc.creatorMarta Giovanetti
dc.creatorVagner Fonseca
dc.creatorLuiz Carlos Junior Alcantara
dc.creatorStephane Tosta
dc.creatorJoilson Xavier
dc.creatorFlavia Levy
dc.creatorCarla de Oliveira
dc.creatorGabriela Menezes
dc.date.accessioned2024-04-23T14:42:46Z
dc.date.accessioned2025-09-09T01:34:19Z
dc.date.available2024-04-23T14:42:46Z
dc.date.issued2022-07-14
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/v14071540
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/1843/67591
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofViruses
dc.rightsAcesso Aberto
dc.subjectGenoma
dc.subjectBrasil
dc.subjectEquino
dc.subjectVírus do Nilo Ocidental
dc.subject.otherWNV
dc.subject.otherNanopore sequencing
dc.subject.otherGenomic monitoring
dc.subject.otherBrazil
dc.titleRetrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil
dc.typeArtigo de periódico
local.citation.epage9
local.citation.issue7
local.citation.spage1540
local.citation.volume14
local.description.resumosettingsOrder Article Reprints Open AccessBrief Report Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil by Hegger Fritsch 1,†,Felicidade Mota Pereira 2,†,Erica Azevedo Costa 1,†ORCID,Vagner Fonseca 3,†ORCID,Stephane Tosta 1,†,Joilson Xavier 1ORCID,Flavia Levy 4,Carla de Oliveira 4,Gabriela Menezes 2,Jaqueline Lima 2,Lenisa Santos 2,Luciana Silva 2,Vanessa Nardy 2,Marcela Kelly Gómez Astete 2ORCID,Beatriz Senra Álvares da Silva Santos 1ORCID,Nágila Rocha Aguiar 1,Maria Isabel Maldonado Coelho Guedes 1ORCID,Guilherme Canhestro de Faria 5,Ronaldo Furtini 5,Safira Rachel Milanez Drumond 5,add Show full author list 1 Laboratorio de Pesquisa em Virologia Animal, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil 2 Laboratório Central de Saúde Pública Prof Goncalo Moniz, Salvador 41745-900, Brazil 3 Organização Pan-Americana de Saúde/Organização Mundial de Saúde, Brasilia 37650-000, Brazil 4 Laboratorio de Flavivirus, lnstituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil 5 Laboratório de Saúde Animal, Instituto Mineiro de Agropecuária, Belo Horizonte 30110-005, Brazil 6 Secretary of Health of the State of Bahia (SESAB), Salvador 40301-110, Brazil 7 Coordenação Geral dos Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde-Brazil, Brasília 70719-040, Brazil 8 Coordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde (CGARB/SVS-MS), Brasilia 37650-000, Brazil 9 Fundação Oswaldo Cruz, Bio-Manguinhos, Rio de Janeiro 21040-360, Brazil 10 Department of Science and Technology for Humans and the Environment, University of Campus Bio-Medico, 00128 Rome, Italy * Authors to whom correspondence should be addressed. † These authors contributed equally to this work. Viruses 2022, 14(7), 1540; https://doi.org/10.3390/v14071540 Submission received: 17 June 2022 / Revised: 10 July 2022 / Accepted: 11 July 2022 / Published: 14 July 2022 (This article belongs to the Special Issue Usutu, West Nile and Tickborne Encephalitis Viruses) Downloadkeyboard_arrow_down Browse Figure Versions Notes Abstract During these past years, several studies have provided serological evidence regarding the circulation of West Nile virus (WNV) in Brazil. Despite some reports, much is still unknown regarding the genomic diversity and transmission dynamics of this virus in the country. Recently, genomic monitoring activities in horses revealed the circulation of WNV in several Brazilian regions. These findings on the paucity of genomic data reinforce the need for prompt investigation of WNV infection in horses, which may precede human cases of encephalitis in Brazil. Thus, in this study, we retrospectively screened 54 suspicious WNV samples collected between 2017 and 2020 from the spinal cord and brain of horses with encephalitis and generated three new WNV genomes from the Ceará and Bahia states, located in the northeastern region of Brazil. The Bayesian reconstruction revealed that at least two independent introduction events occurred in Brazil. The first introduction event appears to be likely related to the North American outbreak, and was estimated to have occurred in March 2013.The second introduction event appears to have occurred in September 2017 and appears to be likely related to the South American outbreak. Together, our results reinforce the importance of increasing the priority of WNV genomic monitoring in equines with encephalitis in order to track the dispersion of this emerging pathogen through the country.
local.identifier.orcidhttps://orcid.org/0000-0002-5396-3818
local.identifier.orcidhttps://orcid.org/0000-0001-5521-6448
local.identifier.orcidhttps://orcid.org/0000-0003-4426-6989
local.identifier.orcidhttps://orcid.org/0000-0003-3916-2018
local.identifier.orcidhttps://orcid.org/0000-0002-1497-4397
local.identifier.orcidhttps://orcid.org/0000-0002-6734-0216
local.identifier.orcidhttps://orcid.org/0000-0002-7684-2883
local.identifier.orcidhttps://orcid.org/0000-0002-5849-7326
local.identifier.orcidhttps://orcid.org/0000-0002-6769-9931
local.publisher.countryBrasil
local.publisher.departmentVET - DEPARTAMENTO DE MEDICINA VETERINÁRIA PREVENTIVA
local.publisher.departmentVETER - ESCOLA DE VETERINARIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1999-4915/14/7/1540

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