Copper(II) nitroaromatic schiff base complexes: synthesis, biological activity and their interaction with dna and albumins

Página do item simplificado
dc.creatorDarliane Aparecida Martins
dc.creatorLucius Flavius Ourives Bomfim Filho
dc.creatorCleiton Moreira da Silva
dc.creatorÂngelo de Fátima
dc.creatorSônia Renaux Wanderley Louro
dc.creatorDenise da Gama Jaen Batista
dc.creatorMaria de Nazaré Correia Soeiro
dc.creatorJoão Ernesto de Carvalho
dc.creatorLetícia Regina de Souza Teixeira
dc.date.accessioned2024-07-26T23:33:46Z
dc.date.accessioned2025-09-09T01:07:50Z
dc.date.available2024-07-26T23:33:46Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.5935/0103-5053.20160150
dc.identifier.issn0103-5053
dc.identifier.urihttps://hdl.handle.net/1843/71978
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subjectSchiff, Bases de
dc.subjectCompostos de cobre
dc.subjectTestes biológicos
dc.subjectDNA
dc.subjectAlbumina
dc.subject.otherSchiff base
dc.subject.otherCopper(II) complexes
dc.subject.otherBiological activity
dc.subject.otherDNA
dc.subject.otherAlbumin
dc.titleCopper(II) nitroaromatic schiff base complexes: synthesis, biological activity and their interaction with dna and albumins
dc.typeArtigo de periódico
local.citation.epage97
local.citation.issue1
local.citation.spage87
local.citation.volume28
local.description.resumoCopper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.
local.identifier.orcidhttps://orcid.org/0000-0001-5102-4633
local.identifier.orcidhttps://orcid.org/0000-0001-9913-8971
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0001-5208-4144
local.identifier.orcidhttps://orcid.org/0000-0003-3790-572X
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://jbcs.sbq.org.br/default.asp?ed=247

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Copper(II) Nitroaromatic Schiff Base Complexes- Synthesis, Biological Activity and (1).pdf
Tamanho:
555.21 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG