Periodontal disease, peri-implant disease and levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TGF-β and TNF-α: follow-up over 5 years

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dc.creatorAlex Martins Gomes
dc.creatorDhelfeson Willya Douglas-de-Oliveira
dc.creatorSérgio Diniz Ferreira
dc.creatorTarcília Aparecida da Silva
dc.creatorLuís Otávio de Miranda Cota
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2025-04-08T20:43:19Z
dc.date.accessioned2025-09-08T22:49:59Z
dc.date.available2025-04-08T20:43:19Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-7757-2018-0316
dc.identifier.issn1678-7765
dc.identifier.urihttps://hdl.handle.net/1843/81395
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Applied Oral Science
dc.rightsAcesso Aberto
dc.subjectPeriodontitis
dc.subjectSaliva
dc.subjectBiomarkers
dc.subjectCytokines
dc.subjectTumor necrosis factor-alpha
dc.subjectTherapeutics
dc.subject.otherPeriodontitis
dc.subject.otherPeri-implant mucositis
dc.subject.otherSaliva
dc.subject.otherBiomarkers
dc.subject.otherCytokines
dc.titlePeriodontal disease, peri-implant disease and levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TGF-β and TNF-α: follow-up over 5 years
dc.typeArtigo de periódico
local.citation.epagee20180322
local.citation.spagee20180316
local.citation.volume27
local.description.resumoObjective The aim of this study was to evaluate the levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TG-β and TNF-α in individuals with diagnosis of peri-implant mucositis in the absence or presence of periodontal and peri-implant maintenance therapy (TMPP) over 5 years. Material and Methods Eighty individuals diagnosed with peri-implant mucositis were divided into two groups: one group that underwent periodontal and peri-implant regularly maintenance therapy, called GTP (n=39), and a second group that received no regular maintenance GNTP (n=41). Each participant underwent a complete periodontal and peri-implant clinical examination. Collection of saliva samples and radiographic examination to evaluate peri-implant bone levels were conducted at two times: initial examination (T1) and after 5 years (T2). The salivary samples were evaluated through ELISA for the following markers: IL-1β, IL-10, RANK, OPG, MMP-2, TGF and TNF-α. Results A higher incidence of peri-implantitis was observed in the GNTP group (43.9%) than in the GTP group (18%) (p=0.000). All individuals (n=12) who presented peri-implant mucositis and had resolution at T2 were in the GTP group. After 5 years, there was an increase in the incidence of periodontitis in the GNTP group compared to the GTP group (p=0.001). The results of the study revealed an increase in the salivary concentration of TNF-α in the GNTP group compared to the GTP group. The other salivary biomarkers that were evaluated did not show statistically significant differences between the two groups. Conclusions The salivary concentration of TNF-α was increased in individuals with worse periodontal and peri-implant clinical condition and in those with a higher incidence of peri-implantitis, especially in the GNTP group. Longitudinal studies in larger populations are needed to confirm these findings and elucidate the role of this biomarker in peri-implant disease.
local.identifier.orcidhttps://orcid.org/0000-0002-4509-2549
local.identifier.orcidhttps://orcid.org/0000-0002-8628-3122
local.identifier.orcidhttps://orcid.org/0000-0002-9830-2554
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0003-1517-5842
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jaos/a/xHT5jRjjhvdQVQrsYjKX7tb/?lang=en

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