MAFLD and NAFLD as underlying etiologies of hepatopathies

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dc.creatorLuanna Silva Monteiro Menezes
dc.creatorBruno Bom Furlan
dc.creatorMarcela Meirelles Tozzi
dc.creatorBernardo Henrique Mendes Correa
dc.creatorPaula Vieira Teixeira Vidigal
dc.creatorFrancisco Guilherme Cancela Penna
dc.creatorCláudia Alves Couto
dc.creatorLuciana Costa Faria
dc.creatorTeresa Cristina de Abreu Ferrari
dc.date.accessioned2025-02-10T18:03:05Z
dc.date.accessioned2025-09-09T00:30:56Z
dc.date.available2025-02-10T18:03:05Z
dc.date.issued2023-10-12
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.15406/jdmdc.2023.10.00263
dc.identifier.issn2379-6383
dc.identifier.urihttps://hdl.handle.net/1843/79823
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMedCrave
dc.rightsAcesso Aberto
dc.subjectTransplante de Fígado
dc.subjectHepatopatia Gordurosa não Alcoólica
dc.subjectCirrose Hepática
dc.subject.otherMetabolic associated fat liver disease
dc.subject.otherNon alcoholic fatty liver disease
dc.subject.otherChronic liver disease
dc.subject.otherLiver cirrhosis
dc.subject.otherliver transplantation
dc.subject.otherCriptogenic liver disease
dc.titleMAFLD and NAFLD as underlying etiologies of hepatopathies
dc.typeArtigo de periódico
local.citation.epage129
local.citation.issue2
local.citation.spage125
local.citation.volume10
local.description.resumoIntroduction: Non-alcoholic fatty liver disease (NAFLD) is closely related to metabolic risk factors and is a highly prevalent disorder. NAFLD concept has evolved into metabolic-associated fatty liver disease (MAFLD), reflecting a more inclusive diagnostic approach related to those metabolic factors. Although the rate of liver transplantation (LT) for NAFLD/MAFLD patients has risen in Western countries, in our midst, it remains a relatively uncommon indication for LT recipients. Simultaneously, cryptogenic cirrhosis (CC) continues to be a prevalent cause of LT in our patient population. Material and methods: A cross-sectional observational study was conducted on 387 adult patients who underwent their first LT for liver cirrhosis (LC) at a Brazilian referral center between 2008 and 2018. The prevalence of clinical and histopathological characteristics of patients with CC and LC of known etiology were analyzed and compared. The diagnosis of MAFLD was reassessed according to established criteria for both groups. Results: Seventy-nine (20.4%) patients had CC, and 308 (79.6%) had LC with a defined etiology; among these, only one had NAFLD. Type 2 diabetes mellitus (T2DM) presented independent association with the CC group (32.5% vs. 21.3%; odds ratio 2.45, 95% confidence interval 1.34-4.46; p=0.003). The other characteristics showed no association with the groups. Fifteen patients (22.7%) previously diagnosed with CC were found to have MAFLD, along with 37 (15.6%), who underwent LT for cirrhosis with a defined etiology. Conclusion: NAFLD/MAFLD were frequent in patients undergoing LT in both groups, and T2DM was more prevalent in the CC group. These findings suggest that NAFLD is probably an unidentified etiology in patients with CC.
local.identifier.orcidhttps://orcid.org/0000-0002-6621-3338
local.identifier.orcidhttps://orcid.org/0000-0002-4583-9980
local.identifier.orcidhttps://orcid.org/0000-0002-8699-8953
local.identifier.orcidhttps://orcid.org/0000-0001-6610-3940
local.identifier.orcidhttps://orcid.org/0000-0002-7003-5159
local.identifier.orcidhttps://orcid.org/0000-0002-2338-5367
local.identifier.orcidhttps://orcid.org/0000-0002-9776-4757
local.identifier.orcidhttps://orcid.org/0000-0001-9459-2294
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://medcraveonline.com/JDMDC/mafld-and-nafld-as-underlying-etiologies-of-hepatopathies.html

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