Cognitive dysfunction in patients with childhood-onset systemic lupus erythematosus may impact treatment

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dc.creatorFlávia Patrícia Senateixeira Santos
dc.creatorGilda Aparecida Ferreira
dc.creatorJonas Jadim de Paula
dc.creatorKalline Cristina Prata de Souza
dc.creatorSandro Luiz Cançado Silva
dc.creatorHumberto Corrêa da Silva Filho
dc.date.accessioned2025-07-28T20:44:50Z
dc.date.accessioned2025-09-09T00:27:11Z
dc.date.available2025-07-28T20:44:50Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s42358-023-00300-8
dc.identifier.issn25233106
dc.identifier.urihttps://hdl.handle.net/1843/83909
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAdvances in Rheumatology
dc.rightsAcesso Aberto
dc.subjectLupus Erythematosus, Systemic
dc.subjectYoung Adult
dc.subjectChild
dc.subjectCognitive Dysfunction
dc.subjectQuality of life
dc.subjectMemory
dc.subject.otherLupus Erythematosus, Systemic
dc.subject.otherYoung Adult
dc.subject.otherChild
dc.subject.otherCognitive Dysfunction
dc.subject.otherQuality of life
dc.subject.otherMemory
dc.titleCognitive dysfunction in patients with childhood-onset systemic lupus erythematosus may impact treatment
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue18
local.citation.spage1
local.citation.volume63
local.description.resumoBackground Cognitive dysfunction (CD) is a widespread manifestation in adult systemic lupus erythematosus (SLE) patients, but this subject is rarely examined in patients with childhood-onset SLE (cSLE). This study aimed to assess the frequency of CD, its associations with lupus clinical manifestations and its impact on the health-related quality of life (HRQL) in young adult cSLE patients. Methods We evaluated 39 cSLE patients older than 18 years. They underwent a rheumatologic evaluation and extensive neuropsychological assessment, encompassing all cognitive domains described by the American College of Rheumatology. HRQL was assessed with the WHOOQOL-BREEF, General Activities of Daily Living Scale (GADL) and Systemic Lupus Erythematosus-specific quality-of-life instrument (SLEQOL). The activity of SLE was evaluated with the modified sle disease activity index (sledai-2k). Results Impairment in at least one cognitive domain was found in 35 (87.2%) patients. The most compromised domains were attention (64.1%), memory (46.2%), and executive functions (38.5%). Patients with cognitive impairment were older, had more accumulated damage and had worse socioeconomic status. Regarding the association between cognitive dysfunction and HRQL, memory impairment was correlated with worse environmental perception and a worse relationship with the treatment. Conclusion: In this study, the frequency of CD in cSLE patients was as high as that in the adult SLE population. CD can significantly impact the response of cSLE patients to treatment, justifying preventive measures in the care of this population. population
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-023-00300-8

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