The emerging role of long noncoding rnas in oral cancer

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dc.creatorCarolina Cavalieri Gomes
dc.creatorSílvia Ferreira de Sousa
dc.creatorGeorge Adrian Calin
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-06-26T22:27:10Z
dc.date.accessioned2025-09-08T23:44:24Z
dc.date.available2025-06-26T22:27:10Z
dc.date.issued2017-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2016.10.006
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/83190
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.rightsAcesso Restrito
dc.subjectRNA
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectTherapeutics
dc.subjectRecurrence
dc.subjectDiagnosis
dc.subjectSaliva
dc.subjectMouth neoplasms
dc.titleThe emerging role of long noncoding rnas in oral cancer
dc.typeArtigo de periódico
local.citation.epage241
local.citation.issue2
local.citation.spage235
local.citation.volume123
local.description.resumoAlthough less than 3% of the genome encodes proteins, at least 75% of the genome is transcribed into RNAs with no protein-coding potential (noncoding RNAs [ncRNAs]). On the basis of their size and the arbitrary 200 nucleotides cutoff, ncRNAs are classified into long ncRNAs (lncRNAs) or small ncRNAs (including microRNAs). Over the last few years, the role of microRNAs in oral squamous cells carcinoma (OSCC) has been extensively addressed, but the possible role of lncRNAs in OSCC remains unclear. We aimed to explore and discuss the potential role of lncRNAs in OSCC. The detection of lncRNAs in saliva holds promise not only as a noninvasive diagnostic tool in OSCC but also in the early detection of oral cancer recurrence. lncRNAs are promising future therapeutic targets in the OSCC scenario, and research in this field may expand greatly in the next decade.
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0002-7427-0578
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440316306198?via%3Dihub

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