CTNNB1 and APC mutations in odontogenic carcinoma with dentinoid

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dc.creatorRogerio Oliveira Gondak
dc.creatorCarolina Cavalieri Gomes
dc.creatorFernanda Viviane Mariano
dc.creatorSilvia Ferreira de Sousa
dc.creatorElisa Carvalho de Siqueira
dc.creatorKatya Pulido Díaz
dc.creatorLeandro Aurélio Liporoni Martins
dc.creatorAlbina Messias de Almeida Milani Altemani
dc.creatorAdalberto Mosqueda-Taylor
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-09-02T21:23:09Z
dc.date.accessioned2025-09-08T22:49:13Z
dc.date.available2025-09-02T21:23:09Z
dc.date.issued2020-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2019.08.017
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/84795
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectMutation
dc.subjectCarcinoma
dc.subjectOdontogenic tumors
dc.subjectGenes
dc.subjectWnt signaling pathway
dc.subjectProteins
dc.subjectOncogenes
dc.subjectGenes, tumor suppressor
dc.titleCTNNB1 and APC mutations in odontogenic carcinoma with dentinoid
dc.typeArtigo de periódico
local.citation.epagee256
local.citation.issue5
local.citation.spagee249
local.citation.volume129
local.description.resumoThe purpose of the present study is to report 2 cases of odontogenic carcinoma with dentinoid, a rare low-grade odontogenic carcinoma associated with facial deformity and bone loss, and to investigate the presence of pathogenic mutations in these samples. By using a next-generation sequencing approach, we sequenced a panel of 50 oncogenes and tumor suppressor genes commonly mutated in human cancer. Microscopic features of both cases revealed solid areas of malignant odontogenic tumor with a large amount of dentinoid material. We identified pathogenic mutations in the genes CTNNB1 and APC, both of which are part of the Wnt-signaling pathway. Consistent with Wnt-signaling activation, both tumors showed strong β-catenin accumulation in the cytoplasm and in the nuclei. The molecular profile of odontogenic carcinoma with dentinoid may help in its diagnosis, as well as in the identification of potential molecular targets for therapy in the future.
local.identifier.orcidhttps://orcid.org/0000-0001-7547-660X
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0003-3694-5025
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0001-7346-471X
local.identifier.orcidhttps://orcid.org/0000-0002-9203-8860
local.identifier.orcidhttps://orcid.org/0000-0002-9944-9734
local.identifier.orcidhttps://orcid.org/0000-0001-8956-6016
local.identifier.orcidhttps://orcid.org/0000-0002-3005-1736
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440319314233?via%3Dihub

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