Treg and Th17 cells in inflammatory periapical disease: a systematic review

Página do item simplificado
dc.creatorAndré Oliveira Naufel de Toledo
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorMila Fernandes Moreira Madeira
dc.creatorLucas Guimarães Abreu
dc.date.accessioned2025-06-13T21:18:56Z
dc.date.accessioned2025-09-09T00:16:27Z
dc.date.available2025-06-13T21:18:56Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2017.vol31.0103
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/82958
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectPeriapical diseases
dc.subjectT-lymphocytes
dc.subjectT-lymphocytes, regulatory
dc.subjectTh17 cells
dc.subjectInflammation
dc.subjectRadicular cyst
dc.subjectPeriapical granuloma
dc.subject.otherPeriapical diseases
dc.subject.otherT-lymphocytes
dc.subject.otherRegulatory
dc.subject.otherTh17 cells
dc.titleTreg and Th17 cells in inflammatory periapical disease: a systematic review
dc.typeArtigo de periódico
local.citation.epage14
local.citation.spage1
local.citation.volume31
local.description.resumoThe process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.
local.identifier.orcidhttps://orcid.org/0000-0002-0619-6820
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.identifier.orcidhttps://orcid.org/0000-0002-1770-9978
local.identifier.orcidhttps://orcid.org/0000-0003-2258-8071
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/LbdHtbWbsF3hTLzzbTckVnq/?lang=en

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Treg and Th17 cells in inflammatory periapical disease a systematic review.pdf
Tamanho:
324.76 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG