Osteoradionecrosis prevalence and associated factors: a ten years retrospective study

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dc.creatorIgor Figueiredo Pereira
dc.creatorRamon Targino Firmino
dc.creatorMeira Henrique Côrtes Meira
dc.creatorBelmiro Cavalcanti do Egito Vasconcelos
dc.creatorVladimir Reimar Augusto de Souza Noronha
dc.creatorVagner Rodrigues Santos
dc.date.accessioned2025-07-07T20:01:42Z
dc.date.accessioned2025-09-08T23:23:34Z
dc.date.available2025-07-07T20:01:42Z
dc.date.issued2018-11
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/doi:10.4317/medoral.22310
dc.identifier.issn1698-6946
dc.identifier.urihttps://hdl.handle.net/1843/83379
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMedicina Oral Patologia Oral y Cirugia Bucal
dc.rightsAcesso Aberto
dc.subjectHead and neck neoplasms
dc.subjectOsteoradionecrosis
dc.subjectRadiotherapy
dc.subjectChemotherapy, adjuvant
dc.subjectEpidemiology
dc.subjectPrevalence
dc.subjectTooth extraction
dc.subjectStomatitis
dc.subjectMandible
dc.subjectAssociation
dc.subjectTobacco use disorder
dc.subjectDentists
dc.subjectMedical records
dc.subject.otherOsteoradionecrosis
dc.subject.otherRadiotherapy
dc.subject.otherAdjuvant chemo-therapy
dc.subject.otherEpidemiology
dc.subject.otherHead and neck neoplasms
dc.titleOsteoradionecrosis prevalence and associated factors: a ten years retrospective study
dc.typeArtigo de periódico
local.citation.epagee638
local.citation.issue6
local.citation.spagee633
local.citation.volume23
local.description.resumoBackground Osteoradionecrosis (ORN) is one of the most serious complications of head and neck radiotherapy and is considered a public health problem worldwide. This study aims to determine the prevalence and associated factors of ORN in patients undergoing radiotherapy for head and neck malignancy. Material and Methods A cross-sectional retrospective study was conducted, in which all medical records of patients undergoing head and neck radiation in the period between 2006 to 2015 (10 years) were examined. Clinical and demographic data were extracted. Multivariate Poisson regression analysis with robust variance was employed to access the relationship between ORN and independent variables (p<0.05; 95% CI). Results The sample comprised 413 medical records of patients undergoing radiotherapy. The prevalence of ORN was 9.7 %. Most participants were males (78.2%). The mean age of subjects was 55 years (± 14 years). The mandible was the main site of occurrence of ORN (85.0%). The following variables were associated with ORN : presence of oral mucositis (PR = 3.03; 95% CI: 1.30-7.03), history of smoking (PR = 0.23; 95% CI: 0.07-0.74), number of teeth removed before radiotherapy (PR = 1.06; 95% CI: 1.01-1.11) and visit to the dentist before radiation (PR = 0.08; 95% CI: 1.02-1.11). Conclusions The prevalence of ORN was low and was associated with the presence of oral mucositis and the number of removed teeth before radiation. Visiting the dentist before radiotherapy and stop-ping smoking were protective factors for ORN.
local.identifier.orcidhttps://orcid.org/0000-0003-1805-4683
local.identifier.orcidhttps://orcid.org/0000-0001-5581-0658
local.identifier.orcidhttps://orcid.org/0000-0002-0747-8950
local.identifier.orcidhttps://orcid.org/0000-0002-6515-1489
local.identifier.orcidhttps://orcid.org/0000-0002-2809-0859
local.identifier.orcidhttps://orcid.org/0000-0002-5370-4867
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.medoraljced.com/medoral/revista/2018/November/23/

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