Potential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish

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dc.creatorIves Charlie-Silva
dc.creatorAndré Luis Branco de Barros
dc.creatorJosé Dias Corrêa Junior
dc.creatorGustavo Batista de Menezes
dc.creatorHirla Costa Silva Fukushima
dc.creatorTássia Flávia Dias Castro
dc.creatorRicardo Carneiro Borra
dc.creatorFelipe Pierezan
dc.creatorNathalie Ferreira Silva de Melo
dc.creatorLeonardo Fernandes Fraceto
dc.creatorNatália Martins Feitosa
dc.creatorJuliana Moreira Mendonça Gomes
dc.creatorDaniela Chemim de Melo Hoyos
dc.creatorCristiano Campos Mattioli
dc.creatorSilas Fernandes Eto
dc.creatorDayanne Carla Fernandes
dc.creatorMarco Antonio de Andrade Belo
dc.creatorJuliana de Oliveira Silva
dc.date.accessioned2024-04-12T20:12:27Z
dc.date.accessioned2025-09-08T23:27:22Z
dc.date.available2024-04-12T20:12:27Z
dc.date.issued2020-09-24
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0238823
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/67131
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPlos One
dc.rightsAcesso Aberto
dc.subjectMucosa
dc.subjectNanocápsulas
dc.subjectPreparações Farmacêuticas
dc.subjectToxicologia
dc.subjectPeixe-Zebra
dc.subject.otherMucosa
dc.subject.otherNanocápsulas
dc.subject.otherPreparações Farmacêuticas
dc.subject.otherToxicologia
dc.subject.otherPeixe-Zebra
dc.titlePotential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish
dc.typeArtigo de periódico
local.citation.epage17
local.citation.issue9
local.citation.spagee0238823
local.citation.volume15
local.description.resumoMucoadhesive polymeric nanocapsules have attracted interest of researchers from different fields from natural sciences because of their ability to interact with the mucosa and increase drug permeation. Anesthesia by immersion causes absorption through the skin and gills of fish, so it is important to evaluate the exposure of these organs to drug nanosystems. Benzocaine (BENZ) is one of the most popular anesthetic agents used in fish anesthesia, but it has drawbacks because of its low bioavailability, resulting in weak absorption after immersion. Here we describe method developed for preparing and characterizing chitosan-coated PLGA mucoadhesive nanoparticles containing BENZ (NPMAs) for zebrafish immersion anesthesia. We determined the lowest effective concentration, characterized the interaction of the mucoadhesive system with fish, measured the anesthetic efficacy, and evaluated possible toxic effects in embryos and adults exposed to the nanoformulations. This study opens perspectives for using nanoformulations prepared with BENZ in aquaculture, allowing reduction of dosage as well as promoting more effective anesthesia and improved interaction with the mucoadhesive system of fish.
local.identifier.orcidhttp://orcid.org/0000-0002-7572-2767
local.identifier.orcidhttp://orcid.org/0000-0002-8623-8524
local.identifier.orcidhttps://orcid.org/0000-0001-6196-2404
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFARMACIA - FACULDADE DE FARMACIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
local.publisher.departmentVET - DEPARTAMENTO DE ZOOTECNIA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238823

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