Pharmaceutical and biomedical applications of native and modified starch: a review

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dc.creatorMaria Aparecida Vieira Teixeira Garcia
dc.creatorCleverson Fernando Garcia
dc.creatorAndré Augusto Gomes Faraco
dc.date.accessioned2022-05-20T22:28:38Z
dc.date.accessioned2025-09-08T22:54:04Z
dc.date.available2022-05-20T22:28:38Z
dc.date.issued2020-07
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipOutra Agência
dc.identifier.doi10.1002/star.201900270
dc.identifier.issn1521-379X
dc.identifier.urihttps://hdl.handle.net/1843/41870
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofStarch - Stärke
dc.rightsAcesso Restrito
dc.subjectAmido
dc.subjectAmido nativo
dc.subjectAmido modificado
dc.subjectAplicações farmacêuticas
dc.subjectAplicações biomédicas
dc.subject.otherDrug delivery
dc.subject.otherExcipients
dc.subject.otherStarch applications
dc.subject.otherStarch modifications
dc.titlePharmaceutical and biomedical applications of native and modified starch: a review
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issue7 - 8
local.citation.spage1
local.citation.volume72
local.description.resumoStarch is a natural, renewable, and biodegradable polymer produced by many plants as a source of stored energy. The structural and functional diversity of starches makes them suitable for different applications. Various physical, chemical, and enzymatic modifications can change and improve functional properties of starch to facilitate its use for different pharmaceutical purposes. Currently, some types of starches—for example, native starch, sodium starch glycolate (chemically modified starch), and pregelatinized starch (physically modified starch)—are approved by the United States Food and Drug Administration (FDA) for use either as an isolated excipient or as a matrix for drug delivery systems in granules, capsules, tablets, suppositories, implants, stents, transdermal, and ophthalmic systems. However, the increasing number of drug moieties with varying physicochemical and stability properties along with the development of new drug production processes and drug delivery systems exert pressure on formulators to search for new excipients that achieve the desired set of functionalities. This paper offers a clear overview of native and modified starches and their use in pharmaceutical and biomedical applications, either as excipients or as drug delivery systems. In addition, some drug release mechanisms, which include encapsulants, micro/nanoparticles hydrogels and scaffolds, are discussed.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/star.201900270

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