Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent covid-19: an exploratory study

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dc.creatorGeraldo Magela Fernandes
dc.creatorLizandra Moura Paravidine Sasaki
dc.creatorGabriela Profírio Jardim-Santos
dc.creatorHeidi Luise Schulte
dc.creatorFelipe Motta
dc.creatorÂngelo Pereira da Silva
dc.creatorAleida Oliveira de Carvalho
dc.creatorYacara Ribeiro Pereira
dc.creatorCaroline de Oliveira Alves
dc.creatorOtávio de Toledo Nóbrega
dc.creatorDavid Alves de Araújo Júnior
dc.creatorLizandra Moura Paravidine Sasaki
dc.creatorDayde Lane Mendonça-Silva
dc.creatorKarina Nascimento Costa
dc.creatorMaria Eduarda Canellas de Castro
dc.creatorLucas Lauand
dc.creatorRodrigo de Resende Nery
dc.creatorRosana Tristão
dc.creatorPatricia Shu Kurizky
dc.creatorOtávio de Toledo Nóbrega
dc.creatorLaila Salmen Espindola
dc.creatorLuiz Cláudio Gonçalves de Castro
dc.creatorPatrícia Nessralla Alpoim
dc.creatorLara Carvalho Godoi
dc.creatorLuci Maria Sant Ana Dusse
dc.creatorJordana Grazziela Alves Coelho-Dos-Reis
dc.creatorLaurence Rodrigues do Amaral
dc.creatorMatheus de Souza Gomes
dc.creatorPedro Luiz Lima Bertarini
dc.creatorJoaquim Pedro Brito-de-Sousa
dc.creatorIsmael Artur da Costa-Rocha
dc.creatorAna Carolina Campi-Azevedo
dc.creatorVanessa Peruhype-Magalhães
dc.creatorAndrea Teixeira-Carvalho
dc.creatorAlberto Moreno Zaconeta
dc.creatorAlexandre Anderson de Sousa Munhoz Soares
dc.creatorValéria Valim
dc.creatorCiro Martins Gomes
dc.creatorCleandro Pires de Albuquerque
dc.creatorOlindo Assis Martins-Filho
dc.creatorLicia Maria Henrique da Mota
dc.date.accessioned2024-11-26T22:43:08Z
dc.date.accessioned2025-09-09T00:03:09Z
dc.date.available2024-11-26T22:43:08Z
dc.date.issued2023-04-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doi10.3389/fimmu.2023.1176898
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/1843/78301
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Immunology
dc.rightsAcesso Aberto
dc.subjectCovi-19
dc.subjectGravidez
dc.subject.otherQuimiocinas
dc.subject.otherCitocinas
dc.subject.otherCovid-19
dc.subject.otherGravidez
dc.subject.otherFator de crescimento
dc.titlePanoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent covid-19: an exploratory study
dc.typeArtigo de periódico
local.citation.epage15
local.citation.spage1
local.citation.volume14
local.description.resumoAbstract Introduction: SARS-CoV-2 infection during pregnancy can induce changes in the maternal immune response, with effects on pregnancy outcome and offspring. This is a cross-sectional observational study designed to characterize the immunological status of pregnant women with convalescent COVID-19 at distinct pregnancy trimesters. The study focused on providing a clear snapshot of the interplay among serum soluble mediators. Methods: A sample of 141 pregnant women from all prenatal periods (1st, 2nd and 3rd trimesters) comprised patients with convalescent SARS-CoV-2 infection at 3-20 weeks after symptoms onset (COVID, n=89) and a control group of pre-pandemic non-infected pregnant women (HC, n=52). Chemokine, pro-inflammatory/regulatory cytokine and growth factor levels were quantified by a high-throughput microbeads array. Results: In the HC group, most serum soluble mediators progressively decreased towards the 2nd and 3rd trimesters of pregnancy, while higher chemokine, cytokine and growth factor levels were observed in the COVID patient group. Serum soluble mediator signatures and heatmap analysis pointed out that the major increase observed in the COVID group related to pro-inflammatory cytokines (IL-6, TNF-α, IL-12, IFN-γ and IL-17). A larger set of biomarkers displayed an increased COVID/HC ratio towards the 2nd (3x increase) and the 3rd (3x to 15x increase) trimesters. Integrative network analysis demonstrated that HC pregnancy evolves with decreasing connectivity between pairs of serum soluble mediators towards the 3rd trimester. Although the COVID group exhibited a similar profile, the number of connections was remarkably lower throughout the pregnancy. Meanwhile, IL-1Ra, IL-10 and GM-CSF presented a preserved number of correlations (≥5 strong correlations in HC and COVID), IL-17, FGF-basic and VEGF lost connectivity throughout the pregnancy. IL-6 and CXCL8 were included in a set of acquired attributes, named COVID-selective (≥5 strong correlations in COVID and <5 in HC) observed at the 3rd pregnancy trimester. Discussion and conclusion: From an overall perspective, a pronounced increase in serum levels of soluble mediators with decreased network interplay between them demonstrated an imbalanced immune response in convalescent COVID-19 infection during pregnancy that may contribute to the management of, or indeed recovery from, late complications in the post-symptomatic phase of the SARS-CoV-2 infection in pregnant women.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1176898/full

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