Effectiveness and safety of anti-TNF therapy for ankylosing spondylitis: a real-world study

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dc.creatorPedro Ricardokömel Pimenta
dc.creatorMichael Ruberson Ribeiro da Silva
dc.creatorJéssica Barreto Ribeiro Dos Santos
dc.creatorAdriana Maria Kakehasi
dc.creatorFrancisco de Assis Acurcio
dc.creatorJuliana Alvares Teodoro
dc.date.accessioned2023-07-17T20:39:21Z
dc.date.accessioned2025-09-08T23:47:31Z
dc.date.available2023-07-17T20:39:21Z
dc.date.issued2021
dc.identifier.doihttps://becarispublishing.com/doi/10.2217/cer-2020-0275
dc.identifier.issn2042-6305
dc.identifier.urihttps://hdl.handle.net/1843/56515
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Comparative Effectiveness Research
dc.rightsAcesso Aberto
dc.subjectEspondilite anquilosante
dc.subjectEficacia
dc.subjectInibidores
dc.subject.otherAnkylosing spondylitis
dc.subject.otherEffectiveness
dc.subject.otherObservational study
dc.subject.otherSafety
dc.subject.otherTumor necrosis factor inhibitors
dc.titleEffectiveness and safety of anti-TNF therapy for ankylosing spondylitis: a real-world study
dc.typeArtigo de periódico
local.citation.epage517
local.citation.issue6
local.citation.spage509
local.citation.volume10
local.description.resumoAim: To evaluate the effectiveness and safety of anti-TNF drugs for ankylosing spondylitis. Materials & methods: A prospective cohort study was performed at a pharmacy in the Brazilian Public Health System. Effectiveness by Bath Ankylosing Spondylitis Disease Activity Index, functionality by Health Assessment Questionnaire Disability Index, quality of life by European Quality of Life Five-Dimensions and safety was assessed at 6 and 12 months of follow-up. Results: About 160 patients started the treatment with adalimumab, etanercept or infliximab. There was a statistically significant improvement in disease activity, functionality and quality of life at 6 and 12 months (p < 0.05). Conclusion: This real-world study has shown that anti-TNF drugs are effective and well tolerated for ankylosing spondylitis patients.
local.identifier.orcidhttps://orcid.org/0000-0003-4024-0108
local.identifier.orcidhttps://orcid.org/0000-0003-2550-7249
local.identifier.orcidhttps://orcid.org/0000-0002-5528-0658
local.identifier.orcidhttps://orcid.org/0000-0001-9411-7493
local.identifier.orcidhttps://orcid.org/0000-0002-5880-5261
local.identifier.orcidhttps://orcid.org/0000-0002-0210-0721
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.2217/cer-2020-0275

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