TiO2 sol-gel coating as a transducer substrate for impedimetric immunosensors

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dc.creatorRicardo Adriano Dorledo de Faria
dc.creatorManuel Noel Paul Georges Houmard
dc.creatorVerônica Aparecida Martins do Rosário
dc.creatorVanessa de Freitas Cunha Lins
dc.creatorLuiz Guilherme Dias Heneine
dc.creatorTulio Matencio
dc.date.accessioned2023-08-09T13:16:51Z
dc.date.accessioned2025-09-08T23:15:48Z
dc.date.available2023-08-09T13:16:51Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.15255/CABEQ.2019.1699
dc.identifier.issn1846-5153
dc.identifier.urihttps://hdl.handle.net/1843/57646
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemical and Biochemical Engineering Quarterly
dc.rightsAcesso Aberto
dc.subjectEletroquímica
dc.subjectEspectroscopia de impedância
dc.subjectDióxido de titânio
dc.subjectBiossensores
dc.subjectDetectores eletroquímicos
dc.subjectVoltametria
dc.subjectCobra venenosa — Veneno
dc.subject.otherTitanium dioxide
dc.subject.otherBiosensor
dc.subject.otherTransducer
dc.subject.otherElectrochemical impedance spectroscopy
dc.titleTiO2 sol-gel coating as a transducer substrate for impedimetric immunosensors
dc.typeArtigo de periódico
local.citation.epage447
local.citation.issue4
local.citation.spage437
local.citation.volume33
local.description.resumoGiven the importance of the transducer elements in the performance of sensors for various applications, as well as the growing search for devices that are capable of providing the response in shorter time, in this work, titanium dioxide was examined as a candidate for application in an electrochemical biosensor. A TiO2 coating deposited by sol-gel method on a silicon wafer was obtained with an anatase crystalline structure, as an n-type semiconductor with donor density equal to 2.954 · 1017 cm–3. Its surface was functionalized to be tested as a biosensor to detect snake venom of the Bothrops genera, and each step of the functionalization was investigated using Electrochemical Impedance Spectroscopy (EIS) and Cyclic voltammetry. Despite being less sensitive than the reference method ELISA, the TiO2-based biosensor was also capable of detecting the analyte of interest at 20 μg mL–1, revealing an increase in its leakage resistance and phase shift after incubation in this solution. Furthermore, the total time for carrying out the biodetection with the TiO2-coated device (41.24 ± 0.05 min) was estimated to be approximately 80 % shorter than that required by the labelled standard assay, which indicates that TiO2 is a promising electrochemical transducer for biosensing applications.
local.identifier.orcidhttps://orcid.org/0000-0002-7025-7042
local.identifier.orcidhttps://orcid.org/0000-0002-1543-5416
local.identifier.orcidhttps://orcid.org/0000-0002-6357-9553
local.identifier.orcidhttps://orcid.org/0000-0003-0707-2691
local.identifier.orcidhttps://orcid.org/0000-0002-5660-8125
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA QUÍMICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttp://silverstripe.fkit.hr/cabeq/past-issues/article/1699

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