A clinical predictive model of renal injury in children with congenital solitary functioning kidney

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dc.creatorIsabel V. Poggiali
dc.creatorEduardo A. Oliveira
dc.creatorAna Cristina Simões e Silva
dc.creatorMariana A. Vasconcelos
dc.creatorCristiane Dos Santos Dias
dc.creatorIzabella R. Gomes
dc.creatorRafaela A. Carvalho
dc.creatorMaria Christina L. Oliveira
dc.creatorSergio V. Pinheiro
dc.creatorRobert H. Mak
dc.date.accessioned2023-08-02T22:03:06Z
dc.date.accessioned2025-09-08T23:42:11Z
dc.date.available2023-08-02T22:03:06Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s00467-018-4111-3
dc.identifier.issn0931041X
dc.identifier.urihttps://hdl.handle.net/1843/57389
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPediatric Nephrology
dc.rightsAcesso Restrito
dc.subjectRim Único
dc.subjectInsuficiência Renal Crônica
dc.subjectHipertensão
dc.subjectProteinuria
dc.subjectInfecções Urinárias
dc.subject.otherSolitary kidney
dc.subject.otherChronic kidney disease
dc.subject.otherHypertension
dc.subject.otherProteinuria
dc.subject.otherUrinary tract infection
dc.titleA clinical predictive model of renal injury in children with congenital solitary functioning kidney
dc.typeArtigo de periódico
local.citation.epage474
local.citation.spage465
local.citation.volume34
local.description.resumoBackground: Solitary functioning kidney (SFK) is an important condition in the spectrum of congenital anomalies of the kidney and urinary tract. The aim of this study was to describe the risk factors for renal injury in a cohort of patients with congenital SFK.Methods: In this retrospective cohort study, 162 patients with SFK were systematically followed up (median, 8.5 years). The primary endpoint was time until the occurrence of a composite event of renal injury, which includes proteinuria, hypertension, and chronic kidney disease (CKD). A predictive model was developed using Cox proportional hazards model and evaluated by c statistics.Results: Among 162 children with SFK included in the analysis, 132 (81.5%) presented multicystic dysplastic kidney, 20 (12.3%) renal hypodysplasia, and 10 (6.2%) unilateral renal agenesis. Of 162 patients included in the analysis, 10 (6.2%) presented persistent proteinuria, 11 (6.8%) had hypertension, 9 (5.6%) developed CKD stage ≥ 3, and 18 (11%) developed the composite outcome. After adjustment by the Cox model, three variables remained as independent predictors of the composite event:creatinine (HR, 3.93; P < 0.001), recurrent urinary tract infection (UTI) (HR, 5.05; P = 0.002), and contralateral renal length atadmission (HR, 0.974; P = 0.002). The probability of the composite event at 10 years of age was estimated as 3%, 11%, and 56% for patients assigned to the low-risk, medium-risk, and high-risk groups, respectively (P < 0.001).Conclusion: Our findings have shown an overall low risk of renal injury for most of infants with congenital SFK. Nevertheless,our prediction model enabled the identification of a subgroup of patients with an increased risk of renal injury over time
local.identifier.orcid0000-0001-6569-3300
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00467-018-4111-3

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