A reanalysis of cognitive-functional performance in older adults: investigating the interaction between normal aging, mild cognitive impairment, mild alzheimer's disease dementia, and depression

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dc.creatorJonas de Paula
dc.creatorMaria Aparecida Camargos Bicalho
dc.creatorRafaela T. Ávila
dc.creatorMarco T. G. Cintra
dc.creatorBreno s. Diniz
dc.creatorMarco Aurelio Romano-Silva
dc.creatorLeandro Fernandes Malloy-Diniz
dc.date.accessioned2023-07-18T20:34:07Z
dc.date.accessioned2025-09-09T00:16:56Z
dc.date.available2023-07-18T20:34:07Z
dc.date.issued2016
dc.identifier.doihttps://doi.org/10.3389/fpsyg.2015.02061
dc.identifier.urihttps://hdl.handle.net/1843/56645
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Psychology
dc.rightsAcesso Aberto
dc.subjectDepressão
dc.subjectAlzheimer, Doença de - Pacientes - Cuidados e tratamento
dc.subject.otherOlder adults
dc.subject.otherDepression
dc.subject.otherCognitive assessment
dc.subject.otherActivities of daily living
dc.subject.otherNeuropsychological assessment
dc.subject.otherMild cognitive impairment
dc.subject.otherAlzheimer’s disease
dc.titleA reanalysis of cognitive-functional performance in older adults: investigating the interaction between normal aging, mild cognitive impairment, mild alzheimer's disease dementia, and depression
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage1
local.citation.volume6
local.description.resumoDepressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer's disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N = 274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA, logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-AD continuum.
local.identifier.orcidhttps://orcid.org/0000-0001-5530-2346
local.identifier.orcidhttps://orcid.org/0000-0001-6298-9377
local.identifier.orcidhttps://orcid.org/0000-0003-0653-1905
local.identifier.orcidhttps://orcid.org/0000-0002-6558-4639
local.identifier.orcidhttps://orcid.org/0000-0002-6606-1354
local.publisher.countryBrasil
local.publisher.departmentFAF - DEPARTAMENTO DE PSICOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fpsyg.2015.02061/full

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