Efficacy of antioxidant supplementation to non-surgical periodontal therapy on metabolic control in type 2 diabetes patients: a network meta-analysis

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dc.creatorElisa Grillo Araújo
dc.creatorDomitilla Marchiori Sant’Anna Leal de Oliveira
dc.creatorCarolina de Castro Martins
dc.creatorCristine Miron Stefan
dc.date.accessioned2024-05-02T22:24:11Z
dc.date.accessioned2025-09-09T00:50:09Z
dc.date.available2024-05-02T22:24:11Z
dc.date.issued2022-03
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/antiox11040621
dc.identifier.issn2076-3921
dc.identifier.urihttps://hdl.handle.net/1843/68066
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAntioxidants
dc.rightsAcesso Aberto
dc.subjectAntioxidants
dc.subjectDiabetes mellitus, type 2
dc.subjectPeriodontitis
dc.subjectPeriodontal debridement
dc.subjectNetwork meta-analysis
dc.subject.otherAntioxidants
dc.subject.otherType 2 diabetes mellitus
dc.subject.otherNon-surgical periodontal therapy
dc.titleEfficacy of antioxidant supplementation to non-surgical periodontal therapy on metabolic control in type 2 diabetes patients: a network meta-analysis
dc.typeArtigo de periódico
local.citation.issue4
local.citation.spage621
local.citation.volume11
local.description.resumoThis network meta-analysis (NMA) investigated the effectiveness of antioxidants as adjuncts to non-surgical periodontal therapy (NSPT) in the glycated hemoglobin (HbA1c) control of type 2 diabetes (T2D) patients with periodontitis. PubMed, Cochrane, LILACS, Web of Science, Scopus, Embase, LIVIVO, and grey literature were searched. Risk of bias was assessed with the RoB v2.0 tool. A frequentist NMA assessed HbA1c improvement, through standardized mean difference under a random-effects model. Certainty of evidence was addressed through the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) partially contextualized framework. Ten randomized controlled clinical trials were included, with 234 patients receiving alpha lipoic acid (ALA), cranberry juice, cranberry juice enriched with omega-3, fenugreek, ginger, grape seed, lycopene, melatonin, omega-3, propolis or vitamin C supplementation to NSPT, and 220 patients receiving NSPT alone or with placebo. Nine studies were meta-analyzed. HbA1c improved when NSPT was combined with propolis, ALA and melatonin supplementation (moderate-to-low certainty), compared to NSPT alone or with placebo. Risk of bias issues were found in eight studies. In conclusion, the use of propolis supplementation to NSPT probably results in HbA1c improvement in T2D patients with periodontitis (large effect with moderate certainty), while ALA and melatonin supplementation may contribute to reduce the HbA1c in T2D patients with periodontitis (large effects with low certainty).
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2076-3921/11/4/621

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