Epithelial–mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model

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dc.creatorEmerson Soares Veloso
dc.creatorHelen Lima Del Puerto
dc.creatorEnio Ferreira
dc.creatorBárbara Andrade de Carvalho
dc.creatorFelipe Henrique de Souza Silva
dc.creatorThaís Salviana Ribeiro
dc.creatorBruna Mendes Lima
dc.creatorCamila Pereira Almeida
dc.creatorVítor Henrique Soares Romão da Silva
dc.creatorSara Aparecida Rocha
dc.creatorMarina Rios de Araújo Campos
dc.date.accessioned2023-10-31T21:36:30Z
dc.date.accessioned2025-09-09T00:57:56Z
dc.date.available2023-10-31T21:36:30Z
dc.date.issued2022-10-22
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-022-22235-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/60398
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectMetástase
dc.subjectTumores
dc.subjectMelanoma
dc.subject.otherMetástase
dc.subject.otherTumores
dc.subject.otherMelanoma
dc.titleEpithelial–mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model
dc.typeArtigo de periódico
local.citation.epage13
local.citation.issue1
local.citation.spage17776
local.citation.volume12
local.description.resumoMelanoma is an aggressive cancer with fast metastatic spread and reduced survival time. One common event during the neoplastic progression is the epithelial–mesenchymal transition (EMT), which enhances invasiveness, cell migration, and metastasis. In this study, we investigated the effects of metformin at EMT in melanoma cell lines B16-F10 and A-375, in vitro, and the impact of EMT downregulation on melanoma progression in vivo. The metformin cells treatment reduces the migration potential in vitro and reduced the development of pulmonary metastases and the expressions of N-cadherin, vimentin, ZEB1, and ZEB2 at the metastases site, in vivo. These results indicate that metformin can promote EMT downregulation impairing the metastatic potential of melanoma cells.
local.identifier.orcidhttps://orcid.org/0000-0002-1835-0303
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-022-22235-8#rightslink

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