Hybrid systems based on gold nanostructures and porphyrins as promising photosensitizers for photodynamic therapy

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dc.creatorDaniele Cristina Ferreira
dc.creatorCamila Soares Monteiro
dc.creatorClaudilene Ribeiro Chaves
dc.creatorGustavo de Almeida Magalhães Sáfar
dc.creatorRoberto Luiz Moreira
dc.creatorMaurício Veloso Brant Pinheiro
dc.creatorDayse Carvalho da Silva Martins
dc.creatorLuiz Orlando Ladeira
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.date.accessioned2022-03-16T20:07:15Z
dc.date.accessioned2025-09-08T23:31:44Z
dc.date.available2022-03-16T20:07:15Z
dc.date.issued2017-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.colsurfb.2016.10.042
dc.identifier.issn0927-7765
dc.identifier.urihttps://hdl.handle.net/1843/40166
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofColloids and Surfaces B: Biointerfaces
dc.rightsAcesso Restrito
dc.subjectFotoquimioterapia
dc.subjectNanoestrutura
dc.subjectNanopartículas
dc.subject.otherPhotodynamic therapy
dc.subject.otherPorphyrin
dc.subject.otherGold nanorods
dc.subject.otherGold nanoparticles
dc.subject.otherReactive oxygen species
dc.titleHybrid systems based on gold nanostructures and porphyrins as promising photosensitizers for photodynamic therapy
dc.title.alternativeSistemas híbridos baseados em nanoestruturas de ouro e porfirinas como fotossensibilizadores promissores para terapia fotodinâmica
dc.typeArtigo de periódico
local.citation.epage307
local.citation.spage297
local.citation.volume150
local.description.resumoGold nanostructures of two different shapes (spheres and rods) were synthesized to form a colloidal hybrid system with 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)porphyrin tosylate salt (H2TM4PyP(OTs)4) (POR) for applications in photodynamic therapy (PDT) using light in the visible spectral range. Electron paramagnetic resonance (EPR) experiments in combination with spin trapping were used for the detection of reactive oxygen species (ROS) and evaluation of the efficiency of these novel hybrid systems as photosensitizers. It is shown that the hybrid system consisting of gold nanorods (AuNR) and porphyrin (POR) is by far more efficient than its isolated components. This enhanced efficiency is explained by a synergetic effect between the AuNR and the porphyrin, wherein a rapid energy transfer from the former to the latter produces a large amount of singlet oxygen followed by its conversion into hydroxyl radicals. The mechanism was investigated using different spin traps and different ROS inhibitors. On the other hand, spherical gold nanoparticles (AuNP) do not show this synergetic effect. The synergetic effect for gold nanorods/POR hybrid is attributed to a larger field enhancement close to the gold nanorod surface in addition to the electrostatic attraction between the components of the hybrid system.
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0927776516307676

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