Thioredoxin and metallothionein: homeostasis-related proteins in lip carcinogenesis

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dc.creatorPatrícia Carlos Caldeira
dc.creatorLaissa dos Santos Silva
dc.creatorAline Carvalho Batista
dc.creatorMaria Cassia Ferreira de Aguiar
dc.date.accessioned2025-06-17T21:38:58Z
dc.date.accessioned2025-09-09T00:58:13Z
dc.date.available2025-06-17T21:38:58Z
dc.date.issued2017-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2017.01.020
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/83014
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Aberto
dc.subjectLip neoplasms
dc.subjectCarcinoma, squamous cell
dc.subjectThioredoxins
dc.subjectMetallothionein
dc.subjectImmune system
dc.subjectColor
dc.subjectImmunohistochemistry
dc.subjectEvaluation study
dc.subjectCytoplasm
dc.subjectCarcinogenesis
dc.subject.otherActinic cheilitis
dc.subject.otherLip neoplasms
dc.subject.otherSquamous cell carcinoma
dc.subject.otherThioredoxin
dc.subject.otherMetallothionein
dc.titleThioredoxin and metallothionein: homeostasis-related proteins in lip carcinogenesis
dc.typeArtigo de periódico
local.citation.epage81
local.citation.spage75
local.citation.volume77
local.description.resumoObjective Thioredoxin (Trx) and metallothionein (MT) are involved in the development of some carcinomas; however, the role of these proteins in labial carcinogenesis has not yet been tested. The aims of the study were to evaluate and to correlate the immunoexpression of Trx and MT in actinic cheilitis, lip squamous cell carcinoma, and normal vermillion lip mucosa. Design Immunohistochemistry was undertaken for Trx and MT in samples of actinic cheilitis, lip squamous cell carcinoma, and normal lip mucosa. Qualitative and semi-quantitative evaluations were conducted. The proportion of stained cells, intensity of staining, and the cell compartment labeled were evaluated. A quickscore index was also calculated by multiplying the values of extension and intensity of nuclear and cytoplasmic staining, respectively, giving a maximum value of 9. Statistics were performed. Results A remarkable nuclear Trx staining was seen in normal lip mucosa and cheilitis, not in carcinoma (p < 0.05). Cytoplasmic Trx expression was widely detected in all lesions (p > 0.05). MT was broadly expressed in nuclei and cytoplasm of carcinoma, but not in normal lip mucosa and cheilitis (p < 0.05). Quickscores were in accordance with the qualitative results. Conclusions The current study showed a different immunopattern of Trx and MT between normal lip mucosa, actinic cheilitis and lip squamous cell carcinoma. The cellular compartment-based analyses evidenced differences that can be related to the proteins function. Considering the relevant roles of these proteins in cellular homeostasis, they seem to have an important role in lip carcinogenesis.
local.identifier.orcidhttps://orcid.org/0000-0002-9179-0145
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996917300286#kwd0005

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