Acquired restrictive strabismus in infancy associated with neurofibromatosis type 2

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dc.creatorVanessawaisberg
dc.creatorGalton Carvalho Vasconcelos
dc.creatorAna Rosa Pimentel de Figueiredo
dc.creatorDébora Marques de Miranda
dc.creatorJuliana Ferreira de Souza
dc.creatorLuiz Oswaldo Carneiro Rodrigues
dc.date.accessioned2023-06-05T20:10:12Z
dc.date.accessioned2025-09-08T23:05:37Z
dc.date.available2023-06-05T20:10:12Z
dc.date.issued2016-01-23
dc.format.mimetypepdf
dc.identifier.doi10.5935/0004-2749.20160041
dc.identifier.issn00042749
dc.identifier.urihttps://hdl.handle.net/1843/54526
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArquivos Brasileiros de Oftalmologia
dc.rightsAcesso Aberto
dc.subjectEstrabismo
dc.subjectNeurofibromatose
dc.subject.otherStrabismus
dc.subject.otherNeurofibromatosis
dc.titleAcquired restrictive strabismus in infancy associated with neurofibromatosis type 2
dc.title.alternativeEstrabismo restritivo adquirido na infância associado à neurofibromatose tipo 2
dc.typeArtigo de periódico
local.citation.epage132
local.citation.issue2
local.citation.spage353
local.citation.volume79
local.description.resumoDear Editors:We would like to add some new information regarding the patient described in the paper entitled, “Surgical treatment of acquired restrictive strabismus in infancy: case report”, published in Arquivos Brasileiros de Oftamologia in 2009(1). We stated that the diagnosis in the reported case was unclear despite extensive investigations. After surgical treatment of acquired restrictive strabismus, the child described remained stable with no other symptoms for approximately 7 years. By the age of 14 years, he developed left hand palsy and skin tumors. One year later, he started experiencing the beginnings of a hearing loss. Magnetic resonance imaging (MRI) of the brain revea led bilateral tumors indicative of vestibular schwannoma (Figure 1). Subsequently, the patient was referred to the Neurofibromatosis Reference Center of the Universidade Federal de Minas Gerais for further evaluation. Diagnosis of neurofibromatosis type 2 (NF2) was then established according to MRI demonstrating bilateral vestibular schwannomas associated with cutaneous schwannomas. NF2 is a dominant, autosomal disease characterized by bilateral vestibular schwannomas with multiple nervous system and skin tumors and is often associated with ocular abnormalities. Although classically considered a disease of adults, the initial signs and symptoms of NF2 may be evident in childhood and often goes unre cognized(2). Diagnosis is difficult in the majority of cases because of its rarity. Initial manifestations of NF2 differ between children and adults. The first sign of disease severity in patients with early-onset NF2 predominantly comprise ocular presentations and weakness in lower motor neuron extremities as opposed to impairment of the eighth nerve in cases of late disease onset(3). Approximately 50% of NF2 patients present with strabismus, ty pically associated with tumors and palsies of cranial nerves III, IV, and VI(4). Although restrictive strabismus is not commonly reported in patients with NF2, it is possible that it was associated with early onset of NF2 in our patient.
local.identifier.orcidhttps://orcid.org/0000-0002-7569-986X
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttp://www.scielo.br/abo

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