Physical exercise, obesity, inflammation and neutrophil extracellular traps (NETs): a review with bioinformatics analysis

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dc.creatorBerenilde Valéria de Oliveira Sousa
dc.creatorDaniela Fernanda de Freitas
dc.creatorRenato Sobral Monteiro Júnior
dc.creatorIara Heloisa Ramos Mendes
dc.creatorJaciara Neves Sousa
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2023-05-05T12:16:53Z
dc.date.accessioned2025-09-09T01:04:27Z
dc.date.available2023-05-05T12:16:53Z
dc.date.issued2021-05-20
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s11033-021-06400-2
dc.identifier.issn1573-4978
dc.identifier.urihttps://hdl.handle.net/1843/52842
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecular Biology Reports
dc.rightsAcesso Restrito
dc.subjectExercícios físicos
dc.subjectObesidade
dc.subjectInflamação
dc.subjectNeutrófilos
dc.subjectBioinformática
dc.titlePhysical exercise, obesity, inflammation and neutrophil extracellular traps (NETs): a review with bioinformatics analysis
dc.typeArtigo de periódico
local.citation.epage4635
local.citation.spage4625
local.citation.volume48
local.description.resumoNeutrophil extracellular traps (NETs) represent an innate organism defense mechanism characterized by neutrophil release of intracellular material to capture any aggressor agent. Elevated NETs release is associated with increased inflammatory response and related diseases, such as obesity. Chronic physical training is one of the main strategies to treat and prevent obesity. The relationship between physical training and NETs is still under study. The present review, followed by a bioinformatics analysis, demonstrates the meaningful connection between physical exercise, obesity, and NETs. The bioinformatics indicated TNF-α as a leading gene after the ontological analysis followed by positive-interleukin-6 regulation, chemokines, and inflammatory response regulation. The main results pointed to a relevant regulatory effect of physical training on NETs release, indicating physical exercise as a possible therapeutic target on modulating NETs and inflammation.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11033-021-06400-2

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