Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats

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dc.creatorThaisa Soares Crespo
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorAlanna Fernandes Paraíso
dc.creatorDeborah de Farias Lelis
dc.creatorPablo Vinicyus Ferreira Chagas
dc.creatorAntônio Sergio Barcala Jorge
dc.creatorWagner Leite Ferreira
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-19T11:16:56Z
dc.date.accessioned2025-09-09T00:55:27Z
dc.date.available2022-08-19T11:16:56Z
dc.date.issued2017-03-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.2174/0929866524666170728155926
dc.identifier.issn1875-5305
dc.identifier.urihttps://hdl.handle.net/1843/44379
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProtein and Peptide Letters
dc.rightsAcesso Aberto
dc.subjectGastrectomia
dc.subjectSistema renina-angiotensina
dc.subjectCirurgia bariátrica
dc.subjectObesidade
dc.subjectTecido adiposo
dc.titleEffects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats
dc.typeArtigo de periódico
local.citation.epage868
local.citation.issue9
local.citation.spage861
local.citation.volume24
local.description.resumoBackground: sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity. Objectives: the present study aimed to assess the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. Methods: male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated. Results: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition, SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin- 6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme (ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p < 0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p = 0.10) and Mas (p = 0.22) receptors. Conclusion: this study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttp://www.eurekaselect.com/article/85070

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