Hydrogen peroxide induces cell proliferation and apoptosis in pulp of rats after dental bleaching in vivo: effects of the dental bleaching in pulp

Página do item simplificado
dc.creatorFrancine Benetti
dc.creatorJoão Eduardo Gomes-filho
dc.creatorLuciana Louzada Ferreira
dc.creatorEdilson Ervolino
dc.creatorAndré Luiz Fraga Briso
dc.creatorGustavo Sivieri Araújo
dc.creatorEloi Dezan Junior
dc.creatorLuciano Tavares Angelo Cintra
dc.date.accessioned2022-09-24T19:30:48Z
dc.date.accessioned2025-09-09T00:27:56Z
dc.date.available2022-09-24T19:30:48Z
dc.date.issued2017-09
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.archoralbio.2017.04.013
dc.identifier.issn00039969
dc.identifier.urihttps://hdl.handle.net/1843/45469
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectCaspase 3
dc.subjectHydrogen peroxide
dc.subjectProliferating cell nuclear antigen
dc.subjectTooth bleaching
dc.subjectInflammation
dc.subjectNecrosis
dc.subject.otherCaspase 3
dc.subject.otherHydrogen peroxide
dc.subject.otherProliferating cell nuclear antigen
dc.subject.otherPulp tissue
dc.subject.otherTooth bleaching.
dc.titleHydrogen peroxide induces cell proliferation and apoptosis in pulp of rats after dental bleaching in vivo: effects of the dental bleaching in pulp
dc.typeArtigo de periódico
local.citation.epage109
local.citation.spage103
local.citation.volume81
local.description.resumoObjective: This study provides an in vivo evaluation of the inflammatory response, levels of cell proliferation and apoptosis, and the presence of necrosis after dental bleaching with two concentrations of hydrogen peroxide (H2O2). Design: Wistar rats were divided into Control (placebo gel), BLUE (20% H2O2, 1×50min), and MAXX (35% H2O2, 3×15min) groups. At 2 and 30days, the rats were killed (n=10). The jaws were processed for histology analysis and PCNA and Caspase-3-cleaved immunohistochemistry, and data were submitted to the Mann-Whitney or ANOVA test (P<0.05). Results: At 2days, the MAXX group showed necrosis and the BLUE group revealed moderate inflammation on the occlusal third of the crown (P<0.05). At 30days, tertiary dentin had formed and there was an absence of inflammation. The level of cell proliferation was higher in the middle third of the BLUE group (P<0.05), and cervical of MAXX at 2days (P<0.05), decreasing at 30days. The apoptosis was present at 2days, particularly in the cervical third of the crown in the bleached groups (P<0.05), with a decrease only at 30days in the BLUE group (P<0.05). Conclusions: The concentration of H2O2 influences effects on the pulp tissue, where a higher concentration of H2O2 can cause necrosis in the pulp and a prolonged effect within the apoptotic process; lower concentrations of H2O2 provide moderate inflammation, cell proliferation and apoptosis with a reduction of these processes over time.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996917301231?via%3Dihub

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG