Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: development, characterization, and ocular biocompatibility

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dc.creatorJéssica Ferreira Cardoso
dc.creatorFernanda Barçante Perasoli
dc.creatorTamires Cunha Almeida
dc.creatorMaria Betânia de Freitas Marques
dc.creatorCibele Rodrigues Toledo
dc.creatorPriscilla Oliveira Gil
dc.creatorHarley da Silva Tavares
dc.creatorMariana Campos da Paz
dc.creatorWagner da Nova Mussel
dc.creatorJuliana Teixeira Magalhães
dc.creatorGlenda Nicioli da Silva
dc.creatorArmando da Silva-Cunha
dc.creatorPaulo Afonso Granjeiro
dc.creatorAlexander M. Klibanov
dc.creatorGisele Rodrigues da Silva
dc.date.accessioned2022-05-23T20:24:49Z
dc.date.accessioned2025-09-09T01:15:54Z
dc.date.available2022-05-23T20:24:49Z
dc.date.issued2021-02-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1016/j.ijbiomac.2020.12.057
dc.identifier.issn0141-8130
dc.identifier.urihttps://hdl.handle.net/1843/41902
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.rightsAcesso Restrito
dc.subjectEndoftalmite bacteriana
dc.subjectVancomicina
dc.subjectÁcido hialurônico
dc.subject.otherN,N-dodecyl, methyl-polyethylenimine (DMPEI)
dc.subject.otherVancomycin-loaded coated nanoparticles
dc.subject.otherHyaluronic acid (HA)
dc.titleVancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: development, characterization, and ocular biocompatibility
dc.typeArtigo de periódico
local.citation.epage341
local.citation.spage330
local.citation.volume169
local.description.resumoVancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid (VCM-DMPEI nanoparticles/HA) were synthesized as an adjuvant for the treatment of bacterial endophthalmitis. The nanoparticles were formulated by experimental statistical design, thoroughly characterized, and evaluated in terms of bactericidal activity and both in vitro and in vivo ocular biocompatibility. The VCM-DMPEI nanoparticles/HA were 154 ± 3 nm in diameter with a 0.197 ± 0.020 polydispersity index; had a + 26.4 ± 3.3 mV zeta potential; exhibited a 93% VCM encapsulation efficiency; and released 58% of the encapsulated VCM over 96 h. VCM and DMPEI exhibited a synergistic bactericidal effect. The VCM-DMPEI nanoparticles/HA were neither toxic to ARPE-19 cells nor irritating to the chorioallantoic membrane. Moreover, the VCM-DMPEI nanoparticles/HA did not induce modifications in retinal functions, as determined by electroretinography, and in the morphology of the ocular tissues. In conclusion, the VCM-DMPEI nanoparticles/HA may be a useful therapeutic adjuvant to treat bacterial endophthalmitis.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0141813020352156#!

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