NPH insulin use by patients with type 2 diabetes mellitus in Minas Gerais, Brazil: prevalence and associated factors

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dc.creatorMichael Ruberson Ribeiro da Silva
dc.creatorLuísa Monteirode Barros Tavares de Melo
dc.creatorJéssica Barreto Ribeiro dos Santos
dc.creatorLeonardo Maurício Diniz
dc.creatorJuliana Alvares
dc.creatorFrancisco de Assis Acurcio
dc.date.accessioned2022-10-19T20:56:49Z
dc.date.accessioned2025-09-08T23:56:30Z
dc.date.available2022-10-19T20:56:49Z
dc.date.issued2017-08-22
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/pds.4275
dc.identifier.issn1099-1557
dc.identifier.urihttps://hdl.handle.net/1843/46422
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Conference on Pharmacoepidemiology & Therapeutic Risk Management
dc.rightsAcesso Aberto
dc.subjectDiabetes mellitus
dc.subjectInsulina
dc.subject.otherDiabetes mellitus
dc.subject.otherInsulina
dc.subject.otherInsulina NPH
dc.titleNPH insulin use by patients with type 2 diabetes mellitus in Minas Gerais, Brazil: prevalence and associated factors
dc.typeArtigo de evento
local.citation.epage127
local.citation.issue33
local.citation.spage127
local.description.resumoBackground: NPH insulin is an important therapeutic alternative for the maintenance of glycemic control in patients with type 2 diabetes mellitus (DM2) in the Brazilian Public Health System (SUS). It is currently considered the third-line treatment in SUS or considered for patients with plasma glucose above 300 mg/ dL at the time of diagnosis. Objectives: To assess the prevalence of NPH insulin use and associated factors among patients with DM2. Methods: Cross-sectional study was conducted in 63 municipalities of Minas Gerais in 2014. The dependent variable was defined as the use of NPH insulin. The independent variables were gender, age, marital status, education, race, self-reported health, diagnosis time, hypoglycemic crisis in the last month, comorbidities, medical visits in the past year, type of health care (public or private), regular physical activity, polypharmacy (use five or more drugs) and interruption of routine activities in the last 15 days. Bivariate and multivariate logistic regression analysis was performed to identify factors associated with NPH insulin use. Results: A total of 2192 patients with DM2 were interviewed and 25% used either insulin or analogue to insulin. The prevalence of NPH insulin use among the participants was 22.1%. Approximately 62% of the NPH insulin users took the medication twice a day, and 33% took it once a day. The following factors were associated with the use of NPH insulin among those patients: diagnostic time above 10 years (OR = 2.78; CI 95% 2.22–3.47), having hypoglycemic crisis in the last month (OR = 2.39; CI 95% 1.85–3.09), using less than 5 drugs (OR = 1.71; CI 95% 1.34– 2.19), having more than 5 comorbidities (OR = 1.48; CI 95% 1.15–1.90), consulting with the doctor more than 3 times on the previous year (OR = 1.46; CI 95% 1.15–1.85) and diabetic foot (OR = 1.53; CI 95% 1.08–2.16) and diabetic neuropathy (OR = 1.40; CI 95% 1.06–1.85) as complications of the DM2. Conclusions: NPH was the most used insulin among the participants. NPH insulin use are associated disease progression characteristics such as having longer diagnostic time, difficulty in glycemic control and complications. Trained professionals are needed to provide adequate care for diabetic patients, especially when using NPH insulin, and therefore to promote a rational use of medicines and to minimize the negative consequences of treatment discontinuation on the health of this population.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/pds.4275

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