Mast cell degranulation in periodontal disease from HIV-infected individuals

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dc.creatorGiovanna Ribeiro Souto
dc.creatorAlessandro Oliveira de Jesus
dc.creatorTakeshi Kato Segundo
dc.creatorPaôlla Freitas Perdigão
dc.creatorFernando de Oliveira Costa
dc.creatorRicardo Alves de Mesquita
dc.date.accessioned2024-06-11T17:47:48Z
dc.date.accessioned2025-09-09T00:45:04Z
dc.date.available2024-06-11T17:47:48Z
dc.date.issued2019-09-10
dc.identifier.doihttps://doi.org/10.20396/bjos.v18i0.8656600
dc.identifier.issn16773225
dc.identifier.urihttps://hdl.handle.net/1843/69128
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Oral Sciences
dc.rightsAcesso Aberto
dc.subjectMast cells
dc.subjectInfections
dc.subjectInflammation
dc.subjectMouth mucosa
dc.subjectCell count
dc.subjectImmune system
dc.subjectHIV
dc.subject.othermast cel
dc.subject.otherHIV Brazilian Journal of Oral Sciences
dc.subject.otherperiodontal disease open acess Mast cell degranulation in periodontal disease from hiv-infected individuals infecção é assunto busca dia 30/04/2024 data publicação 10/09/2019
dc.subject.otherMast cells Infection Inflammation Humans Mouth mucosa
dc.titleMast cell degranulation in periodontal disease from HIV-infected individuals
dc.typeArtigo de periódico
local.citation.epagex
local.citation.issuex
local.citation.spagee191445
local.citation.volume18
local.description.resumoAim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8656600

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