Mature dendritic cell density is affected by smoking habit, lesion size, and epithelial dysplasia in oral leukoplakia samples

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dc.creatorGiovanna Ribeiro Souto
dc.creatorMichelle Danielle Porto Matias
dc.creatorLaiz Fernandes Mendes Nunes
dc.creatorRaquel Conceição Ferreira
dc.creatorRicardo Alves de Mesquita
dc.date.accessioned2025-07-07T19:30:23Z
dc.date.accessioned2025-09-09T00:24:31Z
dc.date.available2025-07-07T19:30:23Z
dc.date.issued2018-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2018.07.008
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/83375
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectLeukoplakia
dc.subjectSmoking
dc.subjectCell count
dc.subjectDendritic cells
dc.subjectTobacco use disorder
dc.subjectLeukoplakia, oral
dc.subject.otherLeukoplakia
dc.subject.otherSmoking habit
dc.subject.otherImmature dendritic cells
dc.subject.otherMature dendritic cells
dc.titleMature dendritic cell density is affected by smoking habit, lesion size, and epithelial dysplasia in oral leukoplakia samples
dc.typeArtigo de periódico
local.citation.epage57
local.citation.spage51
local.citation.volume95
local.description.resumoObjective: To compare the densities of CD1a + immature and CD83+ mature dendritic cells, and inflammatory infiltrate cells between smokers and non-smokers with oral leukoplakia. Parameters associated with malignant transformation were also evaluated. Design: 21 smokers and 23 non-smokers diagnosed with oral leukoplakia were obtained. Densities of inflammatory infiltrate cells were calculated in H&E sections. Immunohistochemistry using anti-CD1a and anti-CD83 was performed and densities were calculated. Comparisons and statistical analyses were performed among the groups and parameters as gender, lesion size, site, and presence of cell dysplasia were analyzed. Results: A lower density of CD83+ cells was observed in smokers compared to non-smokers (P < 0.05). For samples of smokers, a lower density of CD1a + cells, CD83+ cells, and inflammatory infiltrate cells was observed in samples with <10 mm compared to samples ≥10 mm of diameter (P < 0.05), and a lower density of CD83+ cells was also observed between samples without dysplasia compared to samples with dysplasia (P < 0.05). Conclusion: In oral leukoplakia samples, dendritic cell density decreases in the presence of smoking habit, and increases in larger lesions and with epithelial dysplasia. Smoking habit is an external factor that contribute to alteration of the anti-tumoral immune defense system in lesions of oral leucoplakia, reinforcing that smoking elimination is important to control the development of this disease.
local.identifier.orcidhttps://orcid.org/0000-0003-3617-8794
local.identifier.orcidhttps://orcid.org/0000-0002-8598-4170
local.identifier.orcidhttps://orcid.org/0000-0001-8897-9345
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996918303716?via%3Dihub#kwd0005

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