Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology

Página do item simplificado
dc.creatorVictor Angelo Martins Montalli
dc.creatorVera Cavalcanti de Araújo
dc.creatorFabricio Passador-Santos
dc.creatorElizabeth Ferreira Martinez
dc.creatorCristiane Furuse
dc.creatorMaria Cassia Ferreira de Aguiar
dc.creatorFernando Augusto Soares
dc.creatorAndresa Borges Soares
dc.creatorAmy Louise Brown
dc.creatorNey Soares de Araújo
dc.date.accessioned2025-06-09T21:33:43Z
dc.date.accessioned2025-09-09T01:06:33Z
dc.date.available2025-06-09T21:33:43Z
dc.date.issued2017-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12491
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/82877
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectCarcinoma, lobular
dc.subjectProteins
dc.subjectAdenocarcinoma
dc.subjectAdenoma
dc.subjectAdenocarcinoma, papillary
dc.subjectGenes
dc.subjectHistology
dc.subject.otherDOG-1
dc.subject.otherMammaglobin
dc.subject.otherMorphology
dc.subject.otherOrigin
dc.subject.otherPolymorphous low-grade adenocarcinoma.
dc.titleMammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology
dc.typeArtigo de periódico
local.citation.epage187
local.citation.issue3
local.citation.spage182
local.citation.volume46
local.description.resumoBackground: Polymorphous low-grade adenocarcinoma (PLGA) remains a diagnostic challenge for most pathologists due to its large spectrum of histological patterns. In this study, the expression of two new markers recently described for salivary gland tumors was studied in PLGA. Methods: The morphology of 33 cases of PLGA was carefully evaluated using hematoxylin-and-eosin-stained sections and confirmed by immunohistochemistry for cytokeratin 7, vimentin, and S-100. Periodic acid-Schiff with diastase digestion was also used. The expression of mammaglobin and DOG-1 was carried out using the EnVision System. Mammaglobin was assessed according to the percentage of positively stained tumor cells, while DOG-1 was evaluated according to its presence and site. For MCM-2 and Ki-67, markers of proliferation, the labeling index of cell nuclei positivity was evaluated using total cell number. The ETV6-NTRK3 fusion was examined by fluorescence in situ hybridization analysis. Results: The histological patterns of the tumor were classified as lobular or non-lobular. For the non-lobular pattern, tubular, cribriform, glomeruliform, trabecular, and papillary patterns were observed. Mammaglobin was present in all PLGA cases, and its expression was stronger (P = 0.01) in the lobular than in the non-lobular pattern. The expression of DOG-1 was present in the apical portion and cytoplasm of the cells. Proliferation markers were low for all cases independent of histological pattern. Conclusions: Polymorphous low-grade adenocarcinoma has been confirmed to originate from the intercalated duct and to feature high expression of mammaglobin in its lobular pattern resembling that of mammary secretory analogue carcinoma, except for the ETV6 gene rearrangement.
local.identifier.orcidhttps://orcid.org/0000-0002-1927-7718
local.identifier.orcidhttps://orcid.org/0000-0003-4087-889X
local.identifier.orcidhttps://orcid.org/0000-0003-2777-8640
local.identifier.orcidhttps://orcid.org/0000-0002-4991-1185
local.identifier.orcidhttps://orcid.org/0000-0002-1330-1983
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.identifier.orcidhttps://orcid.org/0000-0003-1647-7842
local.identifier.orcidhttps://orcid.org/0000-0001-6112-3096
local.identifier.orcidhttps://orcid.org/0000-0003-1845-0299
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12491

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG