Oral treatment with Davilla Elliptica A. St,-Hil. leaves improves liver steatosis and lipid metabolism on a diet-induced obese mice model

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dc.creatorJaciara Neves Sousa
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSérgio Henrique Sousa Santos
dc.creatorValéria Mafra
dc.creatorBarbhara Mota Marinho
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorLuís Paulo Oliveira
dc.creatorSidnei Tavares dos Reis
dc.creatorTheles Costa
dc.creatorClaudia Regina Vieira
dc.creatorAlfredo Mauricio Batista de Paula
dc.date.accessioned2023-04-12T15:39:29Z
dc.date.accessioned2025-09-09T00:34:08Z
dc.date.available2023-04-12T15:39:29Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.phyplu.2021.100130
dc.identifier.issn2667-0313
dc.identifier.urihttps://hdl.handle.net/1843/51858
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhytomedicine Plus
dc.rightsAcesso Aberto
dc.subjectDileniacea
dc.subjectObesidade
dc.subjectSavanas
dc.subjectCerrados
dc.subjectDoenças induzidas pela nutrição
dc.titleOral treatment with Davilla Elliptica A. St,-Hil. leaves improves liver steatosis and lipid metabolism on a diet-induced obese mice model
dc.typeArtigo de periódico
local.citation.epage7
local.citation.spage1
local.citation.volume1
local.description.resumoBackground: Davilla elliptica A. St.-Hil, also known as “lixeirinha or sambaibinha” is a shrub belonging to the Dilleniaceae family that occurs naturally in the Brazilian savannah (Cerrado). Research studies have shown evidence of its gastroprotective effect, as well as its benefits as an anti-nociceptive, anti-inflammatory, and antioxidant. However, there are no studies testing the potential effects of D. elliptica on treating metabolic parameters and obesity. Purpose: The aim of the present study was to investigate D. elliptica effects on hepatic steatosis induced by a high-fat/high-sugar diet. Methods: Animal experimentation was performed using male Swiss mice divided into four groups: ST (standard control), HLHS (obese control), HLHS+EAF (ethyl-acetate fraction), and HLHS+PL (leaf powder). The groups were treated for four weeks with 0.26 mg/kg/body weight. Results: The main findings of the present study showed that D. elliptica reduced hepatic lipid deposition, body weight, triglycerides, and total cholesterol levels. Gene expression analysis showed that GPX4 and PPARγ mRNA were significantly suppressed in HLHS + EAF mice livers. Conclusion: The present study contributes to elucidating the D. elliptica metabolic role in decreasing GPX4 and PPARγ expression in the HLHS group.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2667031321001123

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