Mechanism of Brassica oleracea performance in bovine infectious mastitis by bioinformatic analysis

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dc.creatorEliane Macedo Sobrinho Santos
dc.creatorAnna Christina de Almeida
dc.creatorHércules Otacílio Santos
dc.creatorAlexsander Rodrigues Cangussu
dc.creatorKattyanne Souza Costa
dc.creatorJanainne Nunes Alves
dc.creatorLuiz Carlos Bertucci Barbosa
dc.creatorRaimundo Wagner Souza Aguiar
dc.date.accessioned2022-06-07T12:49:01Z
dc.date.accessioned2025-09-09T00:26:40Z
dc.date.available2022-06-07T12:49:01Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1016/j.micpath.2019.01.029
dc.identifier.issn0882-4010
dc.identifier.urihttps://hdl.handle.net/1843/42306
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMicrobial Pathogenesis
dc.rightsAcesso Aberto
dc.subjectInfecção
dc.subjectDoenças -- Prevenção
dc.subjectMoléculas
dc.subjectMatéria médica vegetal
dc.titleMechanism of Brassica oleracea performance in bovine infectious mastitis by bioinformatic analysis
dc.typeArtigo de periódico
local.citation.epage29
local.citation.spage19
local.citation.volume129
local.description.resumoBovine mastitis affects dairy cattle worldwide and, despite the existing therapeutic measures, is not totally under control, leading to the need to develop alternative strategies. Brassica oleracea is a phytochemical commonly used in the control and prevention of human and animal diseases. The use of this plant in the treatment of infectious bovine mastitis has been little referenced in the literature and its molecular mechanism of action in this disease has not been clarified yet. This study aimed to reveal, through bioinformatic analysis, the molecular mechanism of action of Brassica oleracea in bovine mastitis. We investigated genes expressed in the signaling pathways of bovine mastitis and Brassica oleracea performance and elaborated the Venn diagram. A gene network was developed using the STRING 10 database. Leader genes were identified by calculating the weighted number of links (WNL). The Network Analyzer plugin for Cytoscape software was used to characterize network topology. For the visualization of highly interconnected regions in the network, the MCODE was used. The BINGO and GFD-Net plugins were used to perform the ontological analysis. The TP53 and MTOR leader genes were identified in the sub-networks of the bovine mastitis signaling pathway and Brassica oleracea performance, respectively. Topological analysis confirmed the leader condition of the genes. Although the overlap of genes in the Venn diagram was not observed, the leader genes were found to be interconnected (confidence = 0.9). In the network that interconnected the leader genes two molecular complexes were detected and the ontological analysis revealed biological processes, cellular components and important molecular functions. It was concluded that Brassica oleracea may be a promising candidate to be included in a mammalian herbal cocktail against infectious bovine mastitis by interfering in the mechanisms of action of genes such as MTOR and TP53.
local.identifier.orcidhttps://orcid.org/ 0000-0001-9836-4117
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0882401017317072

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