Physics, chemistry, and hirshfeld surface analyses of gamma-irradiated thalidomide to evaluate behavior under sterilization doses

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dc.creatorValner Augusto Freitas da Silva da Nova Mussel
dc.creatorMax Passos Ferreira
dc.creatorMaria Betânia de Freitas Marques
dc.creatorMaria Irene Yoshida
dc.creatorMariana Ramos Almeida
dc.creatorBernardo Lages Rodrigues
dc.creatorWagner da Nova Mussel
dc.date.accessioned2022-04-07T23:39:24Z
dc.date.accessioned2025-09-08T23:48:56Z
dc.date.available2022-04-07T23:39:24Z
dc.date.issued2018-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.jpha.2018.01.005
dc.identifier.issn2095-1779
dc.identifier.urihttps://hdl.handle.net/1843/40909
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Pharmaceutical Analysis
dc.rightsAcesso Aberto
dc.subjectTalidomida
dc.subjectRadiação gama
dc.subjectDoses de esterilização
dc.subjectSuperfície de Hirshfeld
dc.subject.otherThalidomide
dc.subject.otherThermal stability
dc.subject.otherPolymorphs
dc.subject.otherGamma irradiation
dc.subject.otherHirshfeld
dc.titlePhysics, chemistry, and hirshfeld surface analyses of gamma-irradiated thalidomide to evaluate behavior under sterilization doses
dc.typeArtigo de periódico
local.citation.epage201
local.citation.issue3
local.citation.spage194
local.citation.volume8
local.description.resumoThalidomide was indicated as a sedative and antiemetic and prescribed for pregnant women. Its tragic teratogenic effects culminated in withdrawal from the market. Since the discovery of its anti-angiogenic and anti-inflammatory actions, thalidomide has been used in the treatment of leprosy and multiple myeloma, which justify studies of its stability. We investigated the effects of irradiation of thalidomide up to 100 kGy (fourfold the usual sterilizing dose for pharmaceutics). The β polymorph of thalidomide was obtained in an isothermal experiment at 270 °C. All samples underwent gamma irradiation for specific times. At different doses, decomposition of the pharmaceutical was not observed up to 100 kGy. The observed effect was angle turning between the phthalimide and glutarimide rings modulated by repulsion towards the carbonyl group, leading to a stable energetic configuration, as measured by the equilibrium in the torsion angle after irradiation. The thalidomide molecule has a center of symmetry, so a full turn starting from 57.3° will lead to an identical molecule. Further irradiation will start the process again. Samples irradiated at 30 and 100 kGy have more compact unit cells and a lower volume, which leads to an increase in the intermolecular hydrogen interaction within the unit cell, resulting in higher thermal stability for polymorph α.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2095177918300054?via%3Dihub

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