Supplementation with kefir improves metabolism and liver inflammation in malnourished mice

Página do item simplificado
dc.creatorFábio Ribeiro dos Santos
dc.creatorGuilherme Henrique Mendes Ribeiro
dc.creatorRenato Sobral Monteiro Júnior
dc.creatorAntônio Sérgio Barcala Jorge
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2024-10-09T19:32:48Z
dc.date.accessioned2025-09-08T23:01:44Z
dc.date.available2024-10-09T19:32:48Z
dc.date.issued2023-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.phanu.2023.100355
dc.identifier.issn2213-4344
dc.identifier.urihttps://hdl.handle.net/1843/77343
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPharmaNutrition
dc.rightsAcesso Restrito
dc.subjectKefir
dc.subjectDesnutrição
dc.subjectEstresse oxidativo
dc.subjectAntioxidantes
dc.subjectProbióticos
dc.subjectDoenças inflamatórias intestinais
dc.titleSupplementation with kefir improves metabolism and liver inflammation in malnourished mice
dc.typeArtigo de periódico
local.citation.spage100355
local.citation.volume26
local.description.resumoBackground: malnutrition causes several changes in body composition and physiological liver function and is commonly related to systemic inflammation, cognitive deficits, and metabolic changes. Kefir is a symbiotic association of yeast and bacteria fermenting milk, used as food supplementation, and is now recognized for its beneficial health properties. In this context, the present study aims to verify the effects promoted by Kefir supplementation in a model of mice malnutrition, evaluating its metabolic effects and liver modulation. Methods: male Swiss mice were divided into four groups with 8 animals each. After the adaptation period, the animals were subjected to two phases of treatment: the caloric restriction phase to promote malnutrition and the renutrition phase. A calorie restriction of 20 % compared to the control group was adopted. Metabolic profile, adipose tissue, liver, biochemical parameters, and gene expression of CAT and SOD were evaluated. Results: the main findings demonstrate an improvement in body weight and biochemical parameters followed by a greater recovery of adipocyte area in the (FR + Kefir) group when compared to the malnourished (FR) group. The data showed an increase in the expression of genes associated with oxidative stress suppression such as superoxide dismutase (SOD) and catalase (CAT) in the groups supplemented with kefir. Conclusions: oral supplementation was able to increase body weight recovery, and adiposity, enabling improvements in metabolism and reducing liver inflammation.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2213434423000270

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG