Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: a molecular and bioinformatic approach

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dc.creatorAlanna Fernandes Paraíso
dc.creatorJaciara Neves Sousa
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorEloa Santos Mangabeira
dc.creatorDeborah de Farias Lelis
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndréa Maria Eleutério de Barros Lima Martins
dc.creatorWilliam James Nogueira Lima
dc.creatorAndré Luiz Sena Guimarães
dc.creatorGeraldo Aclécio Melo
dc.creatorMichaela Schwarz
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-29T13:17:29Z
dc.date.accessioned2025-09-08T22:50:19Z
dc.date.available2022-08-29T13:17:29Z
dc.date.issued2019-11-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2019.116914
dc.identifier.issn0024-3205
dc.identifier.urihttps://hdl.handle.net/1843/44644
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofLife Sciences
dc.rightsAcesso Restrito
dc.subjectÁcido gálico
dc.subjectObesidade
dc.subjectBioinformática
dc.subjectTecido adiposo marrom
dc.subjectHomeostase
dc.subject.otherGallic Acid.
dc.subject.otherSirtuins
dc.subject.otherObesity
dc.subject.otherThermogenesis
dc.subject.otherMetabolism
dc.subject.otherBioinformatic
dc.titleOral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: a molecular and bioinformatic approach
dc.typeArtigo de periódico
local.citation.spage116914
local.citation.volume237
local.description.resumoAims: the aim of the presente study was to examine the effects of oral gallic acid (GA) administration on the brown adipose tissue of obese mice fed with high-fat diet. New mechanisms and interactions pathways in thermogenesis were accessed through bioinformatics analyses. Main methods: swiss male mice were divided into four groups and fed during 60 days with: standard diet, standard diet combined with gallic acid, high-fat diet and high-fat diet combined with gallic acid. Body weight, food intake, and blood parameters (glucose tolerance test, total-cholesterol, high-density low-c, triglyceride and glucose levels) were evaluated. Brown and subcutaneous white adipose tissue histological analysis were performed. SIRT1 and PGC1−α mRNA expression in the brown adipose tissue were assessed. Key findings: our main findings showed that the gallic acid improved glucose tolerance and metabolic parameters. These results were accompanied by bioinformatics analyses that evidenced SIRT1 as main target in the thermogenesis process, confirmed as increased SIRT1 mRNA expression was evidenced in the brown adipose tissue. Significance: together, the data suggest that the gallic acid effect in brown adipose tissue may improve body metabolism, glucose homeostasis and increase thermogenesis.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0024320519308410?via%3Dihub

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