Dynamics of early establishment of SARS-CoV-2 VOC Omicron lineages in Minas Gerais, Brazil
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.
Abstract
Assunto
SARS-CoV-2, Vírus, Genética
Palavras-chave
Omicron, Viral evolution, SARS-CoV-2, Genomic surveillance, Variants of concern
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Endereço externo
https://doi.org/10.3390/v15020585