Kinetics study and hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system

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dc.creatorMaria Betânia de Freitas Marques
dc.creatorBárbara Caroline Rodrigues de Araujo
dc.creatorRita de Cassia de Oliveira Sebastião
dc.creatorWagner da Nova Mussel
dc.creatorMaria Irene Yoshida
dc.date.accessioned2022-05-17T16:04:36Z
dc.date.accessioned2025-09-09T00:50:41Z
dc.date.available2022-05-17T16:04:36Z
dc.date.issued2019-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1016/j.tca.2019.178408
dc.identifier.issn0040-6031
dc.identifier.urihttps://hdl.handle.net/1843/41762
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThermochimica Acta
dc.rightsAcesso Restrito
dc.subjectDrogas cardiovasculares
dc.subjectAnálise térmica
dc.subjectCinética
dc.subject.otherElectron density projection
dc.subject.otherThermal analysis
dc.subject.otherKinetics
dc.subject.otherCompatibility of fixed-dose formulation
dc.subject.otherCompatibility of fixed-dose formulation
dc.titleKinetics study and hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume682
local.description.resumoAtorvastatin calcium trihydrate (ATV) is used for the treatment of hyperlipidemias. The prescribed drug may be associated with an adjuvant diuretic compound such as furosemide (FUR), to treat cardiovascular disorders. This work presents the pharmaceutical development of ATV and FUR mixtures by FTIR, XRPD, and thermal analysis in a long-term study. DSC results indicate atorvastatin water loss and polymorphic furosemide conversion in the temperature range 115–160 °C, as occurs with individual drugs, so it does not attest interaction between them. These are thermal phenomena that occur at a temperature attainable during tableting technology. For this reason, the kinetic study was performed in this temperature range.The kinetics of ATV and FUR was studied by Vyazovkin isoconversional method in the times of zero and 24 months and by a neural network. Hirshfeld surface calculations are also applied. These drugs in static conditions behave as an unreactive mixture. Under heating, for 〈 = 0.3, the interaction between ATV and FUR required activation energy of ˜115 kJ mol−1 at the initial time and in 24 months, this energy increases about 10%, within the experimental error, which confirms a stable system. The ATV crystallinity decreases with heating. These results corroborate for adequate stability of the system in a combined-fixed dose.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0040603119306665

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