High levels of ANXA2 are characteristic of malignant salivary gland tumors

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dc.creatorCláudio Marcelo Cardoso
dc.creatorSabrina Ferreira de Jesus
dc.creatorMarcela Gonçalves de Souza
dc.creatorLorena dos Reis Pereira Queiroz
dc.creatorEloa Mangabeira Santos
dc.creatorErivelton Pereira dos Santos
dc.creatorLuís Paulo Oliveira
dc.creatorCristiane Karine Cordeiro Santos
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorLucyana Conceição Farias
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-25T15:45:49Z
dc.date.accessioned2025-09-09T00:35:05Z
dc.date.available2022-08-25T15:45:49Z
dc.date.issued2019-07-20
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1111/jop.12932
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/44579
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology and Medicine
dc.rightsAcesso Restrito
dc.subjectBoca - Câncer
dc.subjectMetástase
dc.subjectTumores
dc.subjectGlândulas salivares - Doenças
dc.titleHigh levels of ANXA2 are characteristic of malignant salivary gland tumors
dc.typeArtigo de periódico
local.citation.epage934
local.citation.issue10
local.citation.spage929
local.citation.volume48
local.description.resumoObjective: malignant salivary gland tumors (MSGTs) present different phenotypic characteristics and various clinical outcomes, which proved to be a diagnostic challenge. Considering the heterogeneity of MSGT, this study aims to identify molecule related to the nature of MSGT. Methods: for screening, proteomic analysis comparing MSGT with pleomorphic adenoma (PA) and salivary gland was performed. The MSGT-associated protein which presented in the higher number in the Gene Expression Omnibus (GEO) database was selected. To validate the data, immunohistochemistry (IHC) was performed in 14 patients with PA, 22 patients with MSGT, and 14 controls. Results: 16 proteins were associated with MSGT. ANXA2 was the primary protein, according to GEO database analyses. ANXA2 was most expressed in the cell membrane. However, some ANXA2 staining was also observed in the cytoplasm and nucleus. ANXA2 was highly expressed in MSGT in comparison with control. Also, ANXA2 has a higher expression in adenocarcinoma not otherwise specified (ANOS) and myoepithelial carcinoma (MC) in comparison with PA. Conclusion: in conclusion, this study demonstrated that MSGT presented higher levels of ANXA2 in comparison with normal salivary glands. Also, ANXA2 might be interesting as a molecular marker of ANOS and MS.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12932

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