Reduced bone mineral content and density in neurofibromatosis type 1 and its association with nutrient intake

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dc.creatorMárcio Leandro Ribeiro de Souza
dc.creatorAnn Kristine Jansen
dc.creatorLuiz Oswaldo c Rodrigues
dc.creatorDarlene Vilela
dc.creatorAdriana Kakehasi
dc.creatorAline Stangherlin Martins
dc.creatorJuliana Ferreira de Souza
dc.creatorNilton Alves Resende
dc.date.accessioned2023-11-06T21:41:57Z
dc.date.accessioned2025-09-08T23:17:33Z
dc.date.available2023-11-06T21:41:57Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doi10.1590/1806-9282.66.5.666
dc.identifier.issn01044230
dc.identifier.urihttps://hdl.handle.net/1843/60542
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.rightsAcesso Aberto
dc.subjectNeurofibromatosis 1
dc.subjectEating
dc.subjectNutritional Requirements
dc.subjectNutrients
dc.subject.otherneurofibromatosis type 1
dc.subject.otherBone
dc.subject.otherNutrient
dc.subject.otherFood intake
dc.subject.otherNutrition
dc.titleReduced bone mineral content and density in neurofibromatosis type 1 and its association with nutrient intake
dc.typeArtigo de periódico
local.citation.epage672
local.citation.issue5
local.citation.spage666
local.citation.volume66
local.description.resumoNeurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease characterized by multisystem involvement including low bone mineral density (BMD).OBJECTIVE: To assess the bone phenotype of individuals with NF1 and verify its associationwith nutrient intake.METHODS: Twenty-six adults with NF1 underwent bone phenotype assessments using dual-energy X-ray absorptiometry (DXA) andfood intake evaluations. They were compared to 26 unaffected matched control patients. Weight, height, and waist circumference(WC) were measured. DXA provided total body, spine, and hip BMDs and bone mineral content (BMC) for all patients. Food intake was evaluated for energy, macro- and micro-nutrients.RESULTS: Height (1.68 ± 0.1; 1.61 ± 0.1 cm; P = 0.003) and BMC (2.3 ± 0.4; 2.0 ± 0.5 kg; P = 0.046) were lower in the NF1 group. Individuals with NF1 also presented lower total body and spine BMDs (g/cm2) (1.1 ± 0.1, 1.0 ± 0.1, P = 0.036; 1.0 ± 0.1, 0.9 ± 0.1; P = 0.015,respectively). The frequency of total body bone mass below the expected level for patients’ ages was higher in the NF1 group (7.7%;34.6%, P = 0.016). There were no differences in energy consumption. No correlations between BMC and BMD with nutrient intake were observed in the NF1 group.CONCLUSIONS: The NF1 group presented lower BMCs and BMDs. Although a lower consumption of calcium, iron, and vitamin A, and a higher intake of sodium and omega-6 were observed, there was no relationship between bone phenotype and nutrient intake.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE ENFERMAGEM APLICADA
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttp://dx.doi.org/10.1590/1806-9282.66.5.666

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