HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer

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dc.creatorWarne Pedro de Andrade
dc.creatorLetícia da Conceição Braga
dc.creatorLuciana Maria Silva
dc.creatorAgnaldo Lopes da Silva Filho
dc.creatorNikole Gontijo Gonçalves
dc.date.accessioned2023-04-28T20:38:39Z
dc.date.accessioned2025-09-09T00:02:03Z
dc.date.available2023-04-28T20:38:39Z
dc.date.issued2019-11-14
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3892/ol.2019.11095
dc.identifier.issn1792-1082
dc.identifier.urihttps://hdl.handle.net/1843/52686
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOncology Letters
dc.rightsAcesso Aberto
dc.subjectNeoplasias ovarianas
dc.subjectPrognóstico
dc.subjectTratamento farmacológico
dc.subjectProteínas de choque térmico
dc.subjectExpressão gênica
dc.subject.otherOvarian cancer
dc.subject.otherPrognosis
dc.subject.otherResistance to chemotherapy
dc.subject.otherHeat shock proteins
dc.subject.otherGene expression
dc.titleHSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer
dc.typeArtigo de periódico
local.citation.epage367
local.citation.issue1
local.citation.spage359
local.citation.volume19
local.description.resumoAbstract. Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with the presence of chemoresistance contributing to the poor prognosis. Heat Shock Proteins (HSPs) genes are activated in response to pathophysiological stress and serve a role in a variety of stages in carcinogenesis, acting primarily as anti‑apoptotic agents and in chemotherapy resistance in a variety of tumor types. The current study evaluated the HSP gene expression profile in women with ovarian cancer (OC) and their correlation with clinical and pathological aspects of patients with OC. A total of 51 patients included in the current study were divided into four groups: Primary Epithelial Ovarian Cancer (EOC; n=14), metastatic EOC (n=11), ovarian serous cystadenoma (n=7) and no evidence of ovarian malignancy or control groups (n=19). RNA extraction and reverse transcription‑quantitative (RT‑q) PCR was then performed on the samples obtained. RT‑qPCR was performed to compare TNF receptor associated protein 1 (TRAP1), heat shock protein family (HSP) HSPB1, HSPD1, HSPA1A and HSPA1L expression in primary and metastatic EOCs. TRAP1, HSPB1, HSPD1, HSPA1A and HSPA1L gene expression did not differ among groups. HSPA1A, HSPA1L and TRAP1 were revealed to be underexpressed in the primary and metastatic EOC groups, with HSPA1L exhibiting the lowest expression. TRAP1 expression was higher in tumors at stages I/II compared with those at stages III/IV. No correlation was exhibited between HSP expression and age, menarche, menopause, parity, period after menopause initiation, cytoreduction, CA‑125 or overall and disease‑free survival. HSPA1A was negatively correlated with the risk of mortality from OC. The results indicated that the downregulation of HSPA1A, HSPA1L and TRAP1 could be associated with the clinical prognostic features of women with EOC.
local.identifier.orcidhttps://orcid.org/0000-0002-8486-7861
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://www.spandidos-publications.com/10.3892/ol.2019.11095#

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