Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit

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dc.creatorMariana S. de Oliveira
dc.creatorSávio Morato Lacerda Gontijo
dc.creatorMarina S. Teixeira
dc.creatorKarina Imaculada Rosa Teixeira
dc.creatorJacqueline Aparecida Takahashi
dc.creatorRubén Dario Sinisterra Millán
dc.creatorMaría Esperanza Cortés Segura
dc.date.accessioned2023-11-28T18:53:30Z
dc.date.accessioned2025-09-08T23:03:22Z
dc.date.available2023-11-28T18:53:30Z
dc.date.issued2018
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.5935/2446-4775.20180013
dc.identifier.issn2446-4775
dc.identifier.urihttps://hdl.handle.net/1843/61464
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista Fitos
dc.rightsAcesso Aberto
dc.subjectAgentes antineoplásicos
dc.subjectAtividade antifúngica
dc.subjectAntimicóticos
dc.subjectCiclodextrinas
dc.subjectAroeira-vermelha
dc.subjectEssencias e óleos essenciais - Uso terapêutico
dc.subjectMatéria médica vegetal
dc.subjectDiclorometano
dc.subject.otherSchinus terebinthifolius
dc.subject.otherAntifungal
dc.subject.otherAntitumor
dc.subject.otherCyclodextrin
dc.subject.otherMalassezia furfur
dc.titleChemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
dc.typeArtigo de periódico
local.citation.epage146
local.citation.issue2
local.citation.spage135
local.citation.volume12
local.description.resumoIn this study, we isolated and characterized dichloromethane and hexane extracts, complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), of Schinus terebinthifolius fruits. Such complexation may be useful in the formulation of herbal medicines, by improving solubility, or increasing stability by reducing the loss of volatile compounds. The cytotoxicity in osteoblasts, antifungal against Malassezia furfur and antitumor activities were evaluated in Caco-2 cells. The antifungal activity of the extracts and the essential oil in natura or complexed with HP-β-CD against the fungus M. furfur was evaluated by agar diffusion methods and quantitatively by inhibitory concentration (IC). All samples inhibited fungus growth and, when complexed with HP-β-CD, the IC was reduced by 50%. Osteoblast cell viability was not affected by the presence of extracts and oil. The antitumor activity of the extract in dichloromethane was evaluated using Caco-2 cells. The results demonstrated significant reduction in cell viability in the presence of the extract, which makes it a promising candidate for cancer treatment.
local.identifier.orcidhttps://orcid.org/0000-0002-7803-4345
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.arca.fiocruz.br/handle/icict/27868

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