Galectin-3 and fibrosis intensity in Chronic Chagas Cardiomyopathy: a systematic review

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dc.creatorAna Thereza Chaves Lages
dc.creatorAna Laura Grossi de Oliveira
dc.creatorNathalia Sernizon Guimarães
dc.creatorIsabela Cristina Magalhães
dc.creatorCristiane Alves da Silva Menezes
dc.creatorManoel Otávio da Costa Rocha
dc.date.accessioned2025-04-10T13:32:51Z
dc.date.accessioned2025-09-08T23:17:34Z
dc.date.available2025-04-10T13:32:51Z
dc.date.issued2022
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttp://doi.org/10.1590/S1678-9946202264045
dc.identifier.issn1678-9946
dc.identifier.urihttps://hdl.handle.net/1843/81438
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInstituto de medicina tropical de São Paulo
dc.rightsAcesso Aberto
dc.subjectGalectina 3
dc.subjectCardiomiopatia chagásica
dc.subjectDoença de Chagas
dc.subjectFibrose
dc.subject.otherGalectin-3
dc.subject.otherChronic Chagas Cardiomyopathy
dc.subject.otherFibrosis
dc.titleGalectin-3 and fibrosis intensity in Chronic Chagas Cardiomyopathy: a systematic review
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume64
local.description.resumoChronic Chagas Cardiomyopathy (CCC) is the most prevalent type of myocarditis and the main clinical form of the Chagas disease, which has peculiarities such as focal inflammation, structural derangement, hypertrophy, dilation, and intense reparative fibrosis. Many cellular compounds contribute to CCC development. Galectin-3 is a partaker in inflammation and contributes to myocardial fibrosis formation. Some studies showed the connection between Galectin-3 and fibrosis in Chagas disease but are still inconclusive on the guidance for the early implementation of pharmacological therapy. This systematic review evaluated Galectin-3 as a biomarker for fibrosis intensity in CCC. Two independent reviewers have searched five databases (PubMed, EMBASE, Cochrane Library, Scopus, and Lilacs), using the following search terms: galectin-3, biomarkers, fibrosis, Chagas cardiomyopathy, and Chagas disease. Overall, seven studies met the inclusion criteria and made up this review. There were four trials conducted through animal model experiments and three trials with humans. Experimental data in mice indicate an association between Galectin-3 expression and fibrosis in CCC (75% of studies). Data from human studies showed no direct connection between myocardial fibrosis and Galectin-3 expression (80% of studies). Thus, human findings do not provide significant evidence indicating that Galectin-3 is related to fibrosis formation in Chagas disease. Based on the analyzed studies, it is suggested that Galectin-3 might not be a good fibrosis marker in CCC.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG

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