Doença de Alzheimer: estudo da produção de estresse oxidativo e citocina pró e anti-inflamatória induzidos por Hidrocortisona, Resveratrol e Horadrenalina em eucócitos

Abstract

Evidence indicates that the damage caused by free radicals negatively affect chronic diseases and aging can be characterized as a chronic inflammatory process. Since Alzheimer's disease the most common form of dementia and oxidative stress presenting a major role in the pathogenesis of neurodegenerative diseases, this study is to check the modulating effect and / or neuroprotective substances in this imbalance between pro-oxidant levels and anti-oxidants. Having Resveratrol as an anti-oxidant substance is readily obtained by feeding, which makes their use particularly interesting. Along with hydrocortisone and noradrenaline as inherent to the inflammatory process being studied. Are these three substances used in the study of oxidative stress and production of cytokine involved in the inflammatory and the anti-inflammatory response in humanleukocytes.