Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats

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dc.creatorEmisael Stênio Batista Gomes
dc.creatorLucyana Conceição Farias
dc.creatorLuiz Henrique Silveira
dc.creatorCarlos Ícaro de Jesus
dc.creatorRogério Gonçalves da Rocha
dc.creatorGuilherme Veloso Ramos
dc.creatorHanna Thaynara Alves Teixeira Magalhães
dc.creatorManoel Brito Júnior
dc.creatorSérgio Henrique Sousa Santos
dc.creatorBruno Correia Jham
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-23T13:20:13Z
dc.date.accessioned2025-09-09T00:41:45Z
dc.date.available2022-08-23T13:20:13Z
dc.date.issued2019-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2018.10.004
dc.identifier.issn0003-9969
dc.identifier.urihttps://hdl.handle.net/1843/44483
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Aberto
dc.subjectPeriodontite
dc.subjectEndodontia
dc.subjectOsteoporose
dc.subjectStress (Psicologia)
dc.titleConditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats
dc.typeArtigo de periódico
local.citation.epage41
local.citation.spage35
local.citation.volume97
local.description.resumoObjective: because the impact of conditioned fear stress on apical bone resorption is unknown, the aim of the current studywas to use a rat model to evaluate the impact of conditioned fear stress on the bone resorption of inflammatory apical periodontitis lesions. Methods: twenty-five animals were divided into two groups. They underwent a surgical procedure in the first left lower molar tooth to expose the dental pulp and induce inflammatory apical periodontitis lesions through the retention of contamination (bacterial infection) during a 56-day period. The animals in the case group were stressed daily by using electrical stimuli (1.10 mA), whereas the animals in the control group were absent from the stressful stimuli (shocks). The open field test was performed to validate the stress methodology. The jaws were removed and collected for histological and radiographic analyses. Results: stressed animals presented increased levels of bone loss and inflammatory cells in the root apex in comparison with the control group (P = 0.0001). However, no radiographic differences were observed between the groups (P > 0.05). Conclusions: our results demonstrated that conditioned fear stress could modify a periapical lesion by increasing the size of bone loss there. Conditioned fear stress also increased the total number of inflammatory cells compared with the control group. Studies evaluating the impact of conditioned fear stress on human periapical inflammatory lesions should be encouraged.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996918303662

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