Physical exercise-induced cardiovascular and thermoregulatory adjustments are impaired in rats subjected to cutaneous artery denervation

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dc.creatorMilene Rodrigues Malheiros Lima
dc.creatorWashington Pires
dc.creatorIvana Alice Teixeira Fonseca
dc.creatorJulliane Vasconcelos Joviano dos Santos
dc.creatorAnderson José Ferreira
dc.creatorCândido Celso Coimbra
dc.creatorNilo Resende Viana Lima
dc.creatorSamuel Penna Wanner
dc.date.accessioned2023-01-26T15:01:31Z
dc.date.accessioned2025-09-09T00:55:43Z
dc.date.available2023-01-26T15:01:31Z
dc.date.issued2018-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fphys.2018.00074
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/1843/49166
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Physiology
dc.rightsAcesso Aberto
dc.subjectPressão arterial
dc.subjectFadiga
dc.subjectDesempenho físico funcional
dc.subjectPele
dc.subjectSimpatectomia
dc.subjectTemperatura
dc.subjectCorpo - Temperatura - Regulação
dc.subject.otherBlood pressure
dc.subject.otherFatigue
dc.subject.otherPhysical performance
dc.subject.otherVascular remodeling
dc.subject.otherSkin
dc.subject.otherSympathectomy
dc.subject.otherTemperature
dc.subject.otherThermoregulation
dc.titlePhysical exercise-induced cardiovascular and thermoregulatory adjustments are impaired in rats subjected to cutaneous artery denervation
dc.typeArtigo de periódico
local.citation.epage16
local.citation.spage1
local.citation.volume9
local.description.resumoThis study aimed to investigate the chronic effects of caudal artery denervation on morphometric parameters of the tail vascular smooth muscle and on physical exercise-induced thermoregulatory and cardiovascular adjustments in rats. Male Wistar rats were subjected to caudal artery denervation or the sham procedure. Approximately 26–28 days after these procedures, their thermoregulatory and cardiovascular parameters were evaluated at rest and during or following a fatiguing treadmill run. At the end of the experiments, the rats were euthanized, and samples of their tails were removed to evaluate morphometric parameters of the vascular smooth muscle surrounding the caudal artery. Denervated rats showed morphological adaptations, including increased arterial wall thickness and wall-to-lumen ratios. In resting rats and following the fatiguing exercise, caudal artery denervation barely affected the thermoregulatory and cardiovascular parameters evaluated. By contrast, caudal artery denervation attenuated the increase in tail skin temperature, decreased the spontaneous baroreflex sensitivity, and exacerbated the increases in mean arterial pressure in exercising rats. The increased wall-to-lumen ratio of denervated rats correlated negatively with the maximum tail skin temperature attained or cutaneous heat loss sensitivity but correlated positively with the maximum diastolic blood pressure attained during exercise. In conclusion, cutaneous denervation induces vascular remodeling characterized by morphological adaptations of the tail vascular smooth muscle. This vascular remodeling likely underlies the impaired tail heat loss and blood pressure adjustments in denervated rats subjected to physical exercise. Therefore, we have highlighted the importance of cutaneous vascular innervation integrity in thermal and cardiovascular control in stress-challenged rats. In this sense, our findings advance the understanding of thermoregulatory and cardiovascular system reactions after a sustained cutaneous vascular innervation injury, which is essential for the treatment of some diseases, such as Parkinson's disease and type 1 and type 2 diabetes mellitus.
local.identifier.orcidhttps://orcid.org/0000-0001-5163-8424
local.identifier.orcidhttp://orcid.org/0000-0002-4757-914X
local.identifier.orcidhttps://orcid.org/0000-0001-8981-6724
local.identifier.orcidhttps://orcid.org/0000-0002-4659-1032
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fphys.2018.00074/full

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