Lyophilized symbiotic mitigates mucositis induced by 5-fluorouracil

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dc.creatorBruna Machado Savassi
dc.creatorBárbara Fernandes Cordeiro
dc.creatorSara Heloisa da Silva
dc.creatorEmiliano Rosa Oliveira
dc.creatorGiovanna Belo
dc.creatorAlessandra Gomes Figueiroa
dc.creatorMaria Izabel Alves Queiroz
dc.creatorAna Maria Caetano Faria
dc.creatorJuliana Alves
dc.creatorTales Fernando da Silva
dc.creatorGabriela Munis Campos
dc.creatorErick Almeida Esmerino
dc.creatorRamon da Silva Rocha
dc.creatorMônica Queiroz de Freitas
dc.creatorMarcia Cristina Silva
dc.creatorAdriano Gomes da Cruz
dc.creatorKátia Duarte Vital
dc.creatorSimone Odília Antunes Fernandes
dc.creatorValbert Nascimento Cardoso
dc.creatorLeonardo Borges Arcucio
dc.creatorGwénaël Jan
dc.creatorYves Le Loir
dc.creatorAlfonso Gala-Garcia
dc.creatorFillipe Luiz Rosa do Carmo
dc.creatorVasco Azevedo
dc.date.accessioned2023-04-03T20:54:57Z
dc.date.accessioned2025-09-08T23:01:29Z
dc.date.available2023-04-03T20:54:57Z
dc.date.issued2021-12-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.3389/fphar.2021.755871
dc.identifier.issn16639812
dc.identifier.urihttps://hdl.handle.net/1843/51519
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Pharmacology
dc.rightsAcesso Aberto
dc.subjectMucosite
dc.subject5-Fluorouracil
dc.subjectProbiótico
dc.subjectPrebiótico
dc.subject.otherProbiotic
dc.subject.otherChemotherapy
dc.subject.otherPrebiotic
dc.subject.otherImmunomodulant effects
dc.subject.otherSymbiotic
dc.titleLyophilized symbiotic mitigates mucositis induced by 5-fluorouracil
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage1
local.citation.volume12
local.description.resumoMucositis is an adverse effect of cancer chemotherapies using 5-Fluorouracil (5-FU). It is characterized by mucosal inflammation, pain, diarrhea, and weight loss. Some studies reported promising healing effects of probiotic strains, when associated with prebiotics, as adjuvant treatment of mucositis. We developed a lyophilized symbiotic product, containing skimmed milk, supplemented with whey protein isolate (WPI) and with fructooligosaccharides (FOS), and fermented by Lactobacillus casei BL23, Lactiplantibacillus plantarum B7, and Lacticaseibacillus rhamnosus B1. In a mice 5-FU mucositis model, this symbiotic lyophilized formulation was able to reduce weight loss and intestinal permeability. This last was determined in vivo by quantifying blood radioactivity after oral administration of 99mTc-DTPA. Finally, histological damages caused by 5-FU-induced mucositis were monitored. Consumption of the symbiotic formulation caused a reduced score of inflammation in the duodenum, ileum, and colon. In addition, it decreased levels of pro-inflammatory cytokines IL-1β, IL-6, IL-17, and TNF-α in the mice ileum. The symbiotic product developed in this work thus represents a promising adjuvant treatment of mucositis.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fphar.2021.755871/full

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