Cone-beam computed tomography analysis of the effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month human randomized controlled clinical trial

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dc.creatorBernardo Carvalho Dutra
dc.creatorAlcione Maria Soares Dutra de Oliveira
dc.creatorPeterson Antonio Dutra de Oliveira
dc.creatorLuis Otávio de Miranda Cota
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2024-07-04T17:55:55Z
dc.date.accessioned2025-09-08T23:58:09Z
dc.date.available2024-07-04T17:55:55Z
dc.date.issued2022-04
dc.format.mimetypepdf
dc.identifier.issn2518-3745
dc.identifier.urihttps://hdl.handle.net/1843/69716
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Journal of International Academy of Periodontology
dc.rightsAcesso Aberto
dc.subjectEvaluation study
dc.subjectAlendronate
dc.subjectPeriodontitis
dc.subjectCone-beam computed tomography
dc.subjectRadiography
dc.subject.otherCONE BEAM COMPUTED TOMOGRAPHY
dc.subject.otherradiographies
dc.subject.otheraleandronate open acess busca dia 03/07/2024 fao clínica assunto Alendronate'cone-beam computed tomography analysis of the effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month human randomized controlled clinical trial'
dc.subject.otherPeriodontitis open acess busca dia 03/07/2024 fao clínica assunto Alendronate'cone-beam computed tomography analysis of the effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month human randomized controlled clinical trial'
dc.subject.otherClinical trials
dc.subject.otherThe Journal of International Academy of Periodontology periódico
dc.titleCone-beam computed tomography analysis of the effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month human randomized controlled clinical trial
dc.typeArtigo de periódico
local.citation.epage157
local.citation.issue2
local.citation.spage149
local.citation.volume24
local.description.resumoAim: The primary aim of this randomized split-mouth triple-blind placebo-controlled clinical trial was to assess, by means of cone-beam computed tomography (CBCT), the effect of surgical topical use of 1%- Sodium alendronate (ALN) on the reduction of periodontal intrabony defects. Material and methods: Sixty-four intrabony defects from 32 patients with periodontitis were randomly treated with either 1%-ALN gel or placebo gel during periodontal surgeries. Periodontal clinical parameters were recorded at baseline and at 90 (T1) and 180 days (T2) after surgical treatment. Bone defects were evaluated by digital subtraction radiography (DSR) and CBCT at baseline and T2. Results: At T2, intergroup analysis showed significantly better periodontal clinical parameters, higher positive effects on periodontal bone repair (p<0.001) detected through DSR and greater bone filling detected through CBCT (p<0.001) for the ALN group. Moreover, the sensitivity of DSR in relation to CBCT increases with higher bone filling gain, i.e., small filling gains (≤0.5-to-<1.0 mm) are not detected by DSR. Conclusions: Topical application of 1%-ALN gel in intrabony defects showed better clinical results and significantly greater bone filling detected through CBCT compared to a placebo gel after 6 months.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.perioiap.org/publications/60-april-2022/270-cone-beam-computed-tomography-analysis-of-the-effects-of-topical-application-of-1-sodium-alendronate-gel-in-the-surgical-treatment-of-periodontal-intrabony-defects-a-6-month-human-randomized-controlled-clinical-trial

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