The angiotensin converting enzyme 2 (ACE2), gut microbiota, and cardiovascular health

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dc.creatorJoao Marcus Oliveira Andrade
dc.creatorDeborah de Farias Lelis
dc.creatorValeria Mafra Cota
dc.creatorJúnio Cota Silva
dc.date.accessioned2023-01-10T18:32:57Z
dc.date.accessioned2025-09-08T23:24:57Z
dc.date.available2023-01-10T18:32:57Z
dc.date.issued2017
dc.identifier.issn1875-5305
dc.identifier.urihttps://hdl.handle.net/1843/48831
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProtein & Peptide Letters
dc.rightsAcesso Restrito
dc.subjectEnzima conversora da angiotensina 
dc.subjectSistema cardiovascular 
dc.subject.otherRenin-angiotensin system
dc.subject.otherAngiotensin converting enzyme 2
dc.subject.otherGut microbiota
dc.subject.otherCardiovascular health
dc.titleThe angiotensin converting enzyme 2 (ACE2), gut microbiota, and cardiovascular health
dc.typeArtigo de periódico
local.citation.epage832
local.citation.issue9
local.citation.spage827
local.citation.volume24
local.description.resumoBackground: The renin-angiotensin system (RAS) is an important enzymatic system responsible for the regulation of biological functions, such as the arterial pressure, hydroelectrolytic control, vascular vasodilatation/vasoconstriction and more recently metabolic functions. Objectives: The aim of the present review is to discuss the associations between the gut microbiome and the renin-angiotensin system and the influence of their intimate relationship on the cardiovascular health. Methods: A literature review of the main studies published regarding the relationship among the renin-angiotensin system, gut microbiota and cardiovascular health was performed. Results: The association between the ACE2 and gut microbiota has been discussed. It is shown that the ACE2/Ang 1-7 axis modulates the immune response, influencing the microbiota composition, and thus being one of the causes for some diseases physiophatologies, such as diarrhea and intestinal inflammatory disease. Conclusion: The association between RAS and gut microbiota seems to have a strong influence on the genesis of cardiovascular diseases, through direct mechanisms, such as nerve stimulation, or indirectly on metabolic parameters, such as weight, adiposity and lipid profile.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttp://www.eurekaselect.com/article/85062

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